FB2026_02 , released June 18, 2026
Allele: Dmel\AktR45A.tub
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General Information
Symbol
Dmel\AktR45A.tub
Species
D. melanogaster
Name
FlyBase ID
FBal0215852
Feature type
allele
Associated gene
Dmel\Akt
Associated Insertion(s)
Carried in Construct
P{UAS-Akt.R45A}
Key Links
Transgenic product class
missense_variant
(Hietakangas and Cohen, 2007)
Mutagen
Nature of the Allele
Transgenic product class
missense_variant
(Hietakangas and Cohen, 2007)
Mutagen
in vitro construct
(Hietakangas and Cohen, 2007)
Progenitor genotype
Carried in construct
P{UAS-Akt.R45A}
Cytology
Description

A tubulin promoter drives expression of the Akt coding region (the 530 amino acid isoform), mutated to carry a R45A amino acid replacement.

(Hietakangas and Cohen, 2007)
Allele components
Component
Use(s)
Encoded product / tool
Akt
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      Additional Comments
      Genetic Interactions
      Statement
      Reference
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Fails to rescue

      AktR45A.tub fails to rescue Akt1

      (Hietakangas and Cohen, 2007)
      Comments

      Akt1R45A.tub does not rescue the tissue undergrowth seen in homozygous Akt11 clones in the eye.

      (Hietakangas and Cohen, 2007)
      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (2)
      Reported As
      Symbol Synonym
      Akt1R45A.tub
      AktR45A.tub
      Name Synonyms
      Secondary FlyBase IDs
        References (1)