FB2025_05 , released December 11, 2025
Allele: Dmel\Spf45J23
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General Information
Symbol
Dmel\Spf45J23
Species
D. melanogaster
Name
FlyBase ID
FBal0216866
Feature type
allele
Associated gene
Dmel\Spf45
Associated Insertion(s)
P{?SUPor-P}Spf45J23
Carried in Construct
Key Links
Allele class

loss of function allele

Mutagen
Nature of the Allele
Allele class

loss of function allele

(Chaouki and Salz, 2006)
Mutagen
P-element activity
(Chaouki and Salz, 2006)
Progenitor genotype
P{SUPor-P}Spf45KG02503
(Chaouki and Salz, 2006)
Associated Insertion(s)
P{?SUPor-P}Spf45J23
Cytology
Description

Imprecise excision of the P{SUPor-P}Spf45KG02503 insertion. 1kb of the original element remains. Spf45KG02503 is predicted to produce a truncated protein containing the first 312 amino acids of Spf45 followed by an additional three amino acids of novel sequence.

(Chaouki and Salz, 2006)
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 1 )
      Disease
      Interaction
      References
      ameliorates  olivopontocerebellar atrophy
      modeled by Hsap\ATXN182Q.UAS
      (Lim et al., 2008)
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      Spf45J23/Df(2L)D1 larvae show an MMS-sensitive phenotype; they do not survive to adulthood after exposure to 0.075% MMS, in contrast to control larvae.

      Mutants are defective in DNA repair; in assays of excision and repair of the P{hswa} element, mutant flies show an overall reduction in the rate of repair products recovered compared to wild-type controls.

      Mutant females do not show an increased level of X-chromosome nondisjunction during meiosis compared to controls.

      (Chaouki and Salz, 2006)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Suppressor of
      Statement
      Reference

      Spf45J23/Spf45[+] is a suppressor of visible | adult stage phenotype of Hsap\ATXN182Q.UAS, Scer\GAL4GMR.PF

      (Lim et al., 2008)
      Other
      Statement
      Reference

      Spf45J23, Sxl[+]/Sxlf1 has lethal | female | maternal effect phenotype

      (Chaouki and Salz, 2006)
      Phenotype Manifest In
      Suppressor of
      Statement
      Reference

      Spf45J23/Spf45[+] is a suppressor of eye phenotype of Hsap\ATXN182Q.UAS, Scer\GAL4GMR.PF

      (Lim et al., 2008)

      Spf45J23/Spf45[+] is a suppressor of ommatidium phenotype of Hsap\ATXN182Q.UAS, Scer\GAL4GMR.PF

      (Lim et al., 2008)

      Spf45J23/Spf45[+] is a suppressor of interommatidial bristle phenotype of Hsap\ATXN182Q.UAS, Scer\GAL4GMR.PF

      (Lim et al., 2008)
      Additional Comments
      Genetic Interactions
      Statement
      Reference
      Xenogenetic Interactions
      Statement
      Reference

      One copy of Spf45J23 partially suppresses the ommatidial disorganisation and interommatidial bristle loss seen when Hsap\ATXN182Q.Scer\UAS is expressed under the control of Scer\GAL4GMR.PF at 30[o]C.

      (Lim et al., 2008)
      Complementation and Rescue Data
      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (3)
      Reported As
      Symbol Synonym
      Spf45J23
      dRBM17J23
      (Lim et al., 2008)
      spf45J23
      (Chaouki and Salz, 2006)
      Name Synonyms
      Secondary FlyBase IDs
        References (2)