FB2026_02 , released June 18, 2026
Allele: Dmel\mib1C1205S.UAS
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General Information
Symbol
Dmel\mib1C1205S.UAS
Species
D. melanogaster
Name
FlyBase ID
FBal0217436
Feature type
allele
Associated gene
Dmel\mib1
Associated Insertion(s)
Carried in Construct
P{UAS-mib1.C1205S}
Key Links
Transgenic product class
missense_variant
(Bardin and Schweisguth, 2006)
Mutagen
Nature of the Allele
Transgenic product class
missense_variant
(Bardin and Schweisguth, 2006)
Mutagen
in vitro construct
(Bardin and Schweisguth, 2006)
Progenitor genotype
Carried in construct
P{UAS-mib1.C1205S}
Cytology
Description

Expression of mutated mib1 cDNA (amino acid replacement C1205S) is under the control of UASt sequences.

(Bardin and Schweisguth, 2006)
Allele components
Component
Use(s)
Regulatory region(s)
UASt
Encoded product / tool
mib1
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      Animals expressing mib1C1205S.Scer\UAS under the control of Scer\GAL4Ser.PGF post-embryonically (animals are transferred to 28[o]C after embryogenesis to inactivate Scer\GAL80ts.αTub84B which is present in the stock) show nicks in the wing margin.

      (Hamel et al., 2010)

      The formation of wing margin is inhibited in mib1C1205S.Scer\UAS; Scer\GAL4Ser.PGF animals.

      (Bardin and Schweisguth, 2006)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      Suppressed by
      NOT suppressed by
      Statement
      Reference

      Scer\GAL4Ser.PGF, mib1C1205S.UAS has wing margin phenotype, non-suppressible by TomUAS.cLa

      (Bardin and Schweisguth, 2006)
      Additional Comments
      Genetic Interactions
      Statement
      Reference

      Co-expression of α4GT1GS2078 results in strong suppression of the wing phenotypes caused by expression of mib1C1205S.Scer\UAS under the control of Scer\GAL4Ser.PGF post-embryonically (animals are transferred to 28[o]C after embryogenesis to inactivate Scer\GAL80ts.αTub84B which is present in the stock).

      The wing phenotype caused by expression of mib1C1205S.Scer\UAS under the control of Scer\GAL4Ser.PGF post-embryonically (animals are transferred to 28[o]C after embryogenesis to inactivate Scer\GAL80ts.αTub84B which is present in the stock) is suppressed by co-expression of either α4GT1Scer\UAS.cHa or α4GT2Scer\UAS.cHa.

      (Hamel et al., 2010)

      The inhibition of wing margin formation due to mib1C1205S.Scer\UAS; Scer\GAL4Ser.PGF is unnaffected by TomScer\UAS.cLa.

      (Bardin and Schweisguth, 2006)
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Comments
      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (2)
      Reported As
      Symbol Synonym
      mib1C1205S.Scer\UAS
      mib1C1205S.UAS
      Name Synonyms
      Secondary FlyBase IDs
        References (2)