FlyBase Allele Report: Dmel\Dscam1[47]

General Information

Symbol

Dmel\Dscam1⁴⁷

Species

D. melanogaster

Name

FlyBase ID

FBal0217460

Feature type

allele

Associated gene

Dmel\Dscam1

Associated Insertion(s)

Carried in Construct

Also Known As

Dscam⁴⁷

Key Links

Allele class

Mutagen

Nature of the Allele

Allele class

Mutagen

Progenitor genotype

Cytology

Description

In-frame deletion of exon 18 within the cytoplasmic domain.

(Matthews et al., 2007)

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

abnormal neuroanatomy

(Matthews et al., 2007)

abnormal neuroanatomy (with Dscam1²³)

(Matthews et al., 2007)

abnormal neuroanatomy | third instar larval stage (with Dscam1²⁴)

(Zhan et al., 2004)

abnormal neuroanatomy | third instar larval stage (with Dscam1³⁹)

(Zhan et al., 2004)

Phenotype Manifest In

dendrite & abdominal dorsal multidendritic neuron ddaD

(Matthews et al., 2007)

dendrite & abdominal dorsal multidendritic neuron ddaD (with Dscam1²³)

(Matthews et al., 2007)

lobe system of mushroom body | third instar larval stage (with Dscam1³⁹)

(Zhan et al., 2004)

mushroom body medial lobe | third instar larval stage (with Dscam1³⁹)

(Zhan et al., 2004)

mushroom body pedunculus | third instar larval stage (with Dscam1²⁴)

(Zhan et al., 2004)

mushroom body pedunculus | third instar larval stage (with Dscam1³⁹)

(Zhan et al., 2004)

mushroom body vertical lobe | third instar larval stage (with Dscam1³⁹)

(Zhan et al., 2004)

Detailed Description

Statement

Reference

Individual ddaD neurons of Dscam²³/Dscam⁴⁷ and Dscam⁴⁷ homozygous larvae show significant dendrite crossing, indicating defects in self-avoidance.

(Matthews et al., 2007)

Dscam²⁴/Dscam⁴⁷ third instar larvae show defects in axon organisation in the peduncle of the developing mushroom body; in contrast to wild type, multiple phalloidin-positive core fibers are seen in the mutant peduncle.

Dscam³⁹/Dscam⁴⁷ third instar larvae show defects in axon organisation in the peduncle of the developing mushroom body; in contrast to wild type, multiple phalloidin-positive core fibers are seen in the mutant peduncle in 26% of cases.

Core fibers in the mushroom body lobes of Dscam³⁹/Dscam⁴⁷ third instar larvae are highly disorganised and branches frequently fail to segregate to distinct lobes. The dorsal and medial lobes collapse onto each other in 82% of cases.

(Zhan et al., 2004)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Phenotype Manifest In

Additional Comments

Genetic Interactions

Statement

Reference

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Comments

Images (0)

Mutant

Wild-type

Stocks (0)

Notes on Origin

Discoverer

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (3)

Reported As

Symbol Synonym

Dscam1⁴⁷

Dscam47

(Wilhelm et al., 2022)

Dscam⁴⁷

(Matthews et al., 2007, Zhan et al., 2004)

Name Synonyms

Secondary FlyBase IDs

References (3)

Report Sections

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