FB2026_01 , released March 12, 2026
FB2026_01 , released March 12, 2026
Allele: Dmel\Dscam17.27.25.1.UAS.cZa
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General Information
Symbol
Dmel\Dscam17.27.25.1.UAS.cZa
Species
D. melanogaster
Name
FlyBase ID
FBal0217462
Feature type
allele
Associated gene
Dmel\Dscam1
Associated Insertion(s)
Carried in Construct
P{UAS-Dscam1.7.27.25.1.Z}
Key Links
Transgenic product class
wild_type
(Zhan et al., 2004)
Mutagen
Nature of the Allele
Transgenic product class
wild_type
(Zhan et al., 2004)
Mutagen
in vitro construct
(Zhan et al., 2004)
Progenitor genotype
Carried in construct
P{UAS-Dscam1.7.27.25.1.Z}
Cytology
Description

UAS regulatory sequences drive expression of a Dscam1 isoform which contains the alternative exons 4.7, 6.27, 9.25 and 17.1.

(Zhan et al., 2004)
Allele components
Component
Use(s)
Regulatory region(s)
UAS
Encoded product / tool
Dscam1
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 1 )
      Disease
      Interaction
      References
      ameliorates  Down syndrome
      modeled by Dscam105518, fra4
      (Hernández et al., 2023)
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      Expression of Dscam7.27.25.1.Scer\UAS.cZa under the control of Scer\GAL4elav-C155 in large mushroom body clones in a wild-type background results in defects in the mushroom body, including disorganised lobes and ectopic projections of axons outside the mushroom body neuropil into adjacent brain regions.

      (Zhan et al., 2004)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      Suppressor of
      Additional Comments
      Genetic Interactions
      Statement
      Reference
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Fails to rescue

      Scer\GAL4elav-C155/Dscam17.27.25.1.UAS.cZa fails to rescue Dscam1unspecified

      (Zhan et al., 2004)
      Comments

      The branch segregation defects seen in homozygous Dscamunspecified clones in the mushroom body are not rescued by expression of Dscam7.27.25.1.Scer\UAS.cZa under the control of Scer\GAL4elav-C155.

      (Zhan et al., 2004)
      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (3)
      Reported As
      Symbol Synonym
      Dscam17.27.25.1.Scer\UAS.cZa
      Dscam17.27.25.1.UAS.cZa
      Dscam7.27.25.1.Scer\UAS.cZa
      Name Synonyms
      Secondary FlyBase IDs
        References (2)