FlyBase Allele Report: Dmel\Dscam1[UAS.11.31.25.2]

General Information

Symbol

Dmel\Dscam1^{UAS.11.31.25.2}

Species

D. melanogaster

Name

FlyBase ID

FBal0217465

Feature type

allele

Associated gene

Dmel\Dscam1

Associated Insertion(s)

Carried in Construct

P{UAS-Dscam1.11.31.25.2}

Also Known As

UAS-Dscam^11.31.25.2

Key Links

Transgenic product class

wild_type

(Zhan et al., 2004)

Mutagen

in vitro construct

Nature of the Allele

Transgenic product class

wild_type

(Zhan et al., 2004)

Mutagen

in vitro construct

(Matthews et al., 2007, Zhu et al., 2006, Zhan et al., 2004)

Progenitor genotype

Carried in construct

P{UAS-Dscam1.11.31.25.2}

Cytology

Description

UAS regulatory sequences drive expression of a Dscam1 isoform which contains the alternative exons 4.11, 6.31, 9.25 and 17.2.

(Zhan et al., 2004)

Allele components

Component

Use(s)

Regulatory region(s)

UAS

binary expression system - regulatory region

Encoded product / tool

Dscam1

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

abnormal neuroanatomy, with Scer\GAL4^109(2)80

(Matthews et al., 2007)

abnormal neuroanatomy, with Scer\GAL4^elav-C155

(Zhan et al., 2004)

abnormal neuroanatomy, with Scer\GAL4^ppk.PG

(Kim et al., 2013)

abnormal neuroanatomy | third instar larval stage, with Scer\GAL4^ey-OK107

(Zhan et al., 2004)

Phenotype Manifest In

adult mushroom body, with Scer\GAL4^elav-C155

(Zhan et al., 2004)

dendritic arborizing neuron, with Scer\GAL4^109(2)80

(Matthews et al., 2007)

larval dorsal multidendritic neuron ddaC, with Scer\GAL4^ppk.PG

(Kim et al., 2013)

lobe system of adult mushroom body, with Scer\GAL4^elav-C155

(Zhan et al., 2004)

mushroom body pedunculus | third instar larval stage, with Scer\GAL4^ey-OK107

(Zhan et al., 2004)

synapse, with Scer\GAL4^ppk.PG

(Kim et al., 2013)

Detailed Description

Statement

Reference

Overexpression of Dscam1^{Scer\UAS.11.31.25.2} under the control of Scer\GAL4^ppk.PG induces exuberant presynaptic overgrowth.

(Kim et al., 2013)

Larvae expressing Dscam^{11.31.25.2.Scer\UAS} in both the class I vpda neuron and the class III v'pda neuron under the control of Scer\GAL4^109(2)80 show very few overlaps between the two neurons (in contrast to wild type), with the two arbors segregating into nonoverlapping territories.

(Matthews et al., 2007)

Expression of Dscam^{11.31.25.2.Scer\UAS} under the control of Scer\GAL4^elav-C155 in large mushroom body clones in a wild-type background results in defects in the mushroom body, including disorganised lobes and ectopic projections of axons outside the mushroom body neuropil into adjacent brain regions.

Expression of Dscam^{11.31.25.2.Scer\UAS} under the control of Scer\GAL4^OK107 results in defects in the mushroom body of third instar larvae; multiple core fibers are seen in the peduncle (in contrast to wild type).

(Zhan et al., 2004)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Phenotype Manifest In

Additional Comments

Genetic Interactions

Statement

Reference

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Partially rescues

Scer\GAL4^elav-C155/Dscam1^{UAS.11.31.25.2} partially rescues Dscam1^unspecified

(Zhan et al., 2004)

Comments

The branch segregation defects seen in homozygous Dscam^unspecified clones in the mushroom body are significantly rescued by expression of Dscam^{11.31.25.2.Scer\UAS} under the control of Scer\GAL4^elav-C155; 79 +/- 10% of the clones have wild-type morphology.

(Zhan et al., 2004)

Images (0)

Mutant

Wild-type

Stocks (0)

Notes on Origin

Discoverer

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (4)

Reported As

Symbol Synonym

Dscam1^{Scer\UAS.11.31.25.2}

Dscam1^{UAS.11.31.25.2}

Dscam^{11.31.25.2.Scer\UAS}

Dscam^{Scer\UAS.11.31.25.2}

Name Synonyms

Secondary FlyBase IDs

References (4)

Report Sections

Open Close