FB2026_01 , released March 12, 2026
FB2026_01 , released March 12, 2026
Allele: Dmel\Hip142
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General Information
Symbol
Dmel\Hip142
Species
D. melanogaster
Name
FlyBase ID
FBal0217482
Feature type
allele
Associated gene
Dmel\Hip14
Associated Insertion(s)
Carried in Construct
Key Links
Allele class
Mutagen
Nature of the Allele
Allele class
Mutagen
ethyl methanesulfonate
(Ohyama et al., 2007)
Progenitor genotype
Cytology
Description

26bp deletion resulting in a premature stop codon at position 312.

(Ohyama et al., 2007)
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      The electroretinograms (ERGs) of flies in which the eyes are composed of homozygous tissue are abnormal; they lack the on and off transients, but depolarisation is normal.

      Mutant photoreceptors in flies in which the eyes are composed of homozygous tissue have a regular display of terminals in the medulla and show no obvious defects in axonal targeting. Ultrastructural analysis of the photoreceptor synapses in the lamina shows that capitate projections are often shallow in mutants compared with controls.

      Third larval instar neuromuscular junctions (NMJs) have normal morphology in Hip142/Df(3L)brm11 mutants. Ultrastructural analysis of the NMJ boutons indicate that synaptic vesicle morphology and density, T-bar morphology, active zone length and the structure of the subsynaptic reticulum are all normal in the mutants.

      Hip142/Df(3L)brm11 mutant third larval instar NMJs take up less dye than controls in an assay of vesicle cycling.

      Hip142/Df(3L)brm11 mutant third larval instar NMJs have similar miniature excitatory junctional potential (EJP) amplitude and frequency compared to controls. However, the evoked EJP amplitude is reduced compared to controls at 23oC and severely reduced compared to controls at 30oC.

      (Ohyama et al., 2007)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      Additional Comments
      Genetic Interactions
      Statement
      Reference

      Expression of Csp::n-sybTMD.Scer\UAS under the control of Scer\GAL4elav-C155 partially rescues the reduced amplitude of the excitatory junctional potential at the Hip142/Df(3L)brm11 neuromuscular junction at 23oC.

      Expression of Csp::n-sybTMD.Scer\UAS under the control of Scer\GAL4elav-C155 partially rescues the reduced amplitude of the excitatory junctional potential at the Hip141/Hip142 neuromuscular junction at 30oC.

      Expression of Csp2.Scer\UAS under the control of Scer\GAL4elav-C155 does not rescue the reduced amplitude of the excitatory junctional potential at the Hip142/Df(3L)brm11 neuromuscular junction at 23oC.

      Expression of Csp2.Scer\UAS under the control of Scer\GAL4elav-C155 does not rescue the reduced amplitude of the excitatory junctional potential at the Hip141/Hip142 neuromuscular junction at 30oC.

      (Ohyama et al., 2007)
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Images (0)
      Mutant
      Wild-type
      Stocks (1)
      Notes on Origin
      Discoverer

      Associated with: a separable lethal mutation on the chromosome; homozygotes show third larval instar lethality in comparison to the late pupal lethality of hemizygotes with Df(3L)brm11, and the homozygous lethality is not rescued by Hip14+t6.5 (whereas the hemizygous lethality is rescued by Hip14+t6.5).

      (Ohyama et al., 2007)
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (3)
      Reported As
      Symbol Synonym
      3L12
      (Ohyama et al., 2007)
      Hip142
      (Porcellato et al., 2022)
      hip142
      (Ohyama et al., 2007)
      Name Synonyms
      Secondary FlyBase IDs
        References (2)