FB2026_02 , released June 18, 2026
Allele: Dmel\exBQ
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General Information
Symbol
Dmel\exBQ
Species
D. melanogaster
Name
FlyBase ID
FBal0217807
Feature type
allele
Associated gene
Dmel\ex
Associated Insertion(s)
Carried in Construct
Key Links
Genomic Maps

Allele class

loss of function allele

Mutagen
    Nature of the Allele
    Allele class

    loss of function allele

    (Hamaratoglu et al., 2006, Willecke et al., 2006)
    Mutagen
    Progenitor genotype
    Cytology
    Description

    Amino acid replacement: ?32term.

    (Hamaratoglu et al., 2006)
    Mutations Mapped to the Genome
    Curation Data
    Type
    Location
    Additional Notes
    References
    point_mutation
    2L:438,515..438,515 [+]
    Nucleotide change:

    A438515T

    Amino acid change:

    R31term | ex-PA; R31term | ex-PB

    Reported amino acid change:

    ?32term

    Comment:

    Inferred location of nonsense mutation based on amino acid sequence.

    (Hamaratoglu et al., 2006)
    Variant Molecular Consequences
    Associated Sequence Data
    DDBJ / EMBL / GenBank
    DNA sequence
    Protein sequence
     
    UniProtKB/Swiss-Prot
      UniProtKB/TrEMBL
        Expression Data
        Reporter Expression
        Additional Information
        Statement
        Reference
         
        Marker for
        Reflects expression of
        Reporter construct used in assay
        Human Disease Associations
        Disease Ontology (DO) Annotations
        Models Based on Experimental Evidence ( 0 )
        Disease
        Evidence
        References
        Modifiers Based on Experimental Evidence ( 0 )
        Disease
        Interaction
        References
        Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
         
        Disease-implicated variant(s)
         
        Phenotypic Data
        Phenotypic Class
        Phenotype Manifest In
        Detailed Description
        Statement
        Reference

        exBQ mutant retina exhibit only a few more pigment cells than wild-type, indciating a slight increase in the number of interommatidial cells.

        (Willecke et al., 2006)
        External Data
        Interactions
        Show genetic interaction network for Enhancers & Suppressors
        Phenotypic Class
        Suppressor of
        Statement
        Reference

        exBQ is a suppressor of decreased size | adult stage phenotype of PatroninGD11946, Scer\GAL4en.PU

        (Yang and Choi, 2021)

        exBQ is a suppressor of visible | adult stage phenotype of PatroninGD11946, Scer\GAL4en.PU

        (Yang and Choi, 2021)
        NOT Suppressor of
        Statement
        Reference

        ex[+], exBQ, Mer[+], Mer4 is a non-suppressor of increased cell death phenotype of Scer\GAL4GMR.PF, hpoUAS.cUa

        (Hamaratoglu et al., 2006)

        exBQ/exBQ is a non-suppressor of visible phenotype of hpoUAS.cUa

        (Hamaratoglu et al., 2006)
        Other
        Statement
        Reference

        exBQ, ft422 has abnormal size phenotype

        (Willecke et al., 2006)
        Phenotype Manifest In
        NOT Enhanced by
        Statement
        Reference

        exBQ has interommatidial bristle phenotype, non-enhanceable by ft422

        (Willecke et al., 2006)
        Suppressor of
        Statement
        Reference

        exBQ is a suppressor of wing phenotype of PatroninGD11946, Scer\GAL4en.PU

        (Yang and Choi, 2021)
        NOT Suppressor of
        Additional Comments
        Genetic Interactions
        Statement
        Reference

        The adult eye phenotype and the loss of interommmatidial cells seen in hpoScer\UAS.cUa; Scer\GAL4GMR.PF mid-pupal retinas is not suppressed by exBQ/exBQ or in exBQ Mer4 double homozygous clones.

        The increase in cell death seen in late third instar eye discs from hpoScer\UAS.cUa; Scer\GAL4GMR.PF animals is not suppressed by exBQ/+; Mer4/+.

        (Hamaratoglu et al., 2006)

        ft422;exBQ double mutant retinae do not exhibit large numbers of interommatidial cells and resemble the exBQ and ft422 single mutant phenotypes. However, ft422;exBQ double mutant clones exhibit stronger overgrowth phenotypes than the single mutants in the head outside the retina, that ft and ex may also have functions independent of each other.

        (Willecke et al., 2006)
        Xenogenetic Interactions
        Statement
        Reference
        Complementation and Rescue Data
        Comments
        Images (0)
        Mutant
        Wild-type
        Stocks (1)
        Notes on Origin
        Discoverer
        External Crossreferences and Linkouts ( 0 )
        Synonyms and Secondary IDs (1)
        Reported As
        Symbol Synonym
        exBQ
        (Yang and Choi, 2021, Pascual et al., 2017, Baumgartner et al., 2010, Hamaratoglu et al., 2006, Willecke et al., 2006)
        Name Synonyms
        Secondary FlyBase IDs
          References (7)