FB2026_02 , released June 18, 2026
Allele: Dmel\borc05496
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General Information
Symbol
Dmel\borc05496
Species
D. melanogaster
Name
FlyBase ID
FBal0218005
Feature type
allele
Associated gene
Dmel\bor
Associated Insertion(s)
PBac{PB}borc05496
Carried in Construct
Key Links
Genomic Maps

Allele class
Mutagen
    Nature of the Allele
    Allele class
    Mutagen
    Progenitor genotype
    Associated Insertion(s)
    PBac{PB}borc05496
    Cytology
    Description
    Allele components
    Component
    Use(s)
    Also carries
    FRT
    Mutations Mapped to the Genome
    Associated Sequence Data
    DDBJ / EMBL / GenBank
    DNA sequence
    Protein sequence
     
    UniProtKB/Swiss-Prot
      UniProtKB/TrEMBL
        Expression Data
        Reporter Expression
        Additional Information
        Statement
        Reference
         
        Marker for
        Reflects expression of
        Reporter construct used in assay
        Human Disease Associations
        Disease Ontology (DO) Annotations
        Models Based on Experimental Evidence ( 1 )
        Modifiers Based on Experimental Evidence ( 0 )
        Disease
        Interaction
        References
        Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
         
        Disease-implicated variant(s)
         
        Phenotypic Data
        Phenotypic Class
        Phenotype Manifest In

        adult somatic muscle cell of thorax | adult stage (with borT2A-Gal4), with Scer\GAL4bor-T2A-Gal4, borL83V.UAS.Tag:V5

        (Yap et al., 2021)

        adult somatic muscle cell of thorax | adult stage (with borT2A-Gal4), with Scer\GAL4bor-T2A-Gal4, borR176W.UAS.Tag:V5

        (Yap et al., 2021)

        autolysosome | adult stage | increased number (with borT2A-Gal4), with Scer\GAL4bor-T2A-Gal4, borL83V.UAS.Tag:V5

        (Yap et al., 2021)

        autolysosome | adult stage | increased number (with borT2A-Gal4), with Scer\GAL4bor-T2A-Gal4, borR176W.UAS.Tag:V5

        (Yap et al., 2021)

        autophagosome | adult stage | increased number (with borT2A-Gal4), with Scer\GAL4bor-T2A-Gal4, borL83V.UAS.Tag:V5

        (Yap et al., 2021)

        autophagosome | adult stage | increased number (with borT2A-Gal4), with Scer\GAL4bor-T2A-Gal4, borR176W.UAS.Tag:V5

        (Yap et al., 2021)

        embryonic brain (with borT2A-Gal4)

        (Yap et al., 2021)

        embryonic ventral nerve cord (with borT2A-Gal4)

        (Yap et al., 2021)

        larval somatic muscle cell | first instar larval stage (with Df(3R)Exel7329)

        (Harel et al., 2016)

        lysosome | adult stage | increased number (with borT2A-Gal4), with Scer\GAL4bor-T2A-Gal4, borL83V.UAS.Tag:V5

        (Yap et al., 2021)

        lysosome | adult stage | increased number (with borT2A-Gal4), with Scer\GAL4bor-T2A-Gal4, borR176W.UAS.Tag:V5

        (Yap et al., 2021)

        mitochondrial crista | adult stage (with borT2A-Gal4), with Scer\GAL4bor-T2A-Gal4, borL83V.UAS.Tag:V5

        (Yap et al., 2021)

        mitochondrial crista | adult stage (with borT2A-Gal4), with Scer\GAL4bor-T2A-Gal4, borR176W.UAS.Tag:V5

        (Yap et al., 2021)

        mitochondrion | adult stage (with borT2A-Gal4), with Scer\GAL4bor-T2A-Gal4, borL83V.UAS.Tag:V5

        (Yap et al., 2021)

        mitochondrion | adult stage (with borT2A-Gal4), with Scer\GAL4bor-T2A-Gal4, borR176W.UAS.Tag:V5

        (Yap et al., 2021)

        mitochondrion | embryonic stage | increased number (with borT2A-Gal4)

        (Yap et al., 2021)

        mitochondrion | first instar larval stage (with Df(3R)Exel7329)

        (Harel et al., 2016)

        neuron projection | embryonic stage (with borT2A-Gal4)

        (Yap et al., 2021)

        peripheral nervous system | embryonic stage (with borT2A-Gal4)

        (Yap et al., 2021)
        Detailed Description
        Statement
        Reference

        borT2A-Gal4/borc05496 embryos show central nervous system defects (brain mis-location, twisted and shrunken VNC, and partial absence of the VNC) and peripheral nervous system defects (partial absence of peripheral nervous system cells, misguided neural tracks, and failure of correct cell specification), as well as increased mitochondrial content.

        borT2A-Gal4/borc05496 adults expressing either borL83V.UAS.Tag:V5 or borR176W.UAS.Tag:V5 under the control of Scer\GAL4bor-T2A-Gal4 (the intrinsic driver of borT2A-Gal4) are short lived and show a progressive decrease in climbing and flight activity; thorax muscles exhibit (mostly) smaller mitochondria, with cristae defects, and increased autophagic intermediates.

        (Yap et al., 2021)

        borc05496/Df(3R)Exel7329 transheterozygous first instar larvae show a significant decrease in the density of mitochondria in muscles, as compared to controls.

        (Harel et al., 2016)
        External Data
        Interactions
        Show genetic interaction network for Enhancers & Suppressors
        Phenotypic Class
        NOT Suppressor of
        Statement
        Reference

        bor[+]/borc05496 is a non-suppressor of bang sensitive | semidominant phenotype of parabss1

        (Howlett et al., 2013)
        Phenotype Manifest In
        Additional Comments
        Genetic Interactions
        Statement
        Reference

        The bang sensitive phenotype seen in parabss1/+ mutant females is not suppressed by one copy of borc05496.

        (Howlett et al., 2013)
        Xenogenetic Interactions
        Statement
        Reference
        Complementation and Rescue Data
        Images (0)
        Mutant
        Wild-type
        Stocks (1)
        Notes on Origin
        Discoverer
        External Crossreferences and Linkouts ( 0 )
        Synonyms and Secondary IDs (1)
        Reported As
        Symbol Synonym
        borc05496
        (Tan et al., 2012)
        Name Synonyms
        Secondary FlyBase IDs
          References (5)