FB2026_01 , released March 12, 2026
FB2026_01 , released March 12, 2026
Allele: Dmel\Msp3005prime
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General Information
Symbol
Dmel\Msp3005prime
Species
D. melanogaster
Name
FlyBase ID
FBal0218043
Feature type
allele
Associated gene
Dmel\Msp300
Associated Insertion(s)
Carried in Construct
Key Links
Allele class
Mutagen
    Nature of the Allele
    Allele class
    Mutagen
    Progenitor genotype
    Caused by aberration
    Df(2L)Msp300-5
    Cytology
    Description

    Df(2L)Msp-300-5 removes the 5' section of the Msp-300 locus, including the calponin homology domains, between P{XP}d07933 and P{XP}d01768.

    (Technau and Roth, 2008)
    Mutations Mapped to the Genome
    Curation Data
    Type
    Location
    Additional Notes
    References
    Variant Molecular Consequences
    Associated Sequence Data
    DDBJ / EMBL / GenBank
    DNA sequence
    Protein sequence
     
    UniProtKB/Swiss-Prot
      UniProtKB/TrEMBL
        Expression Data
        Reporter Expression
        Additional Information
        Statement
        Reference
         
        Marker for
        Reflects expression of
        Reporter construct used in assay
        Human Disease Associations
        Disease Ontology (DO) Annotations
        Models Based on Experimental Evidence ( 0 )
        Disease
        Evidence
        References
        Modifiers Based on Experimental Evidence ( 0 )
        Disease
        Interaction
        References
        Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
         
        Disease-implicated variant(s)
         
        Phenotypic Data
        Phenotypic Class
        Phenotype Manifest In
        Detailed Description
        Statement
        Reference

        Msp-3005prime homozygotes are larval lethal. They do not display any obvious phenotype and move normally. Over time, the movements become slower and the larvae die before entering the second instar. There is no detectable difference in the arrangement or the movement of the body wall muscles of wild-type and mutant individuals when observing the larvae in polarised light.

        Msp-3005prime germline clones lay normal eggs, with no observable defects in nuclear position or nuclear architecture in the egg chambers.

        (Technau and Roth, 2008)
        External Data
        Interactions
        Show genetic interaction network for Enhancers & Suppressors
        Phenotypic Class
        Phenotype Manifest In
        Additional Comments
        Genetic Interactions
        Statement
        Reference

        Female Msp-3005prime;klarmarb-BX12 double mutants lay normal eggs and exhibit wild-type egg chambers.

        (Technau and Roth, 2008)
        Xenogenetic Interactions
        Statement
        Reference
        Complementation and Rescue Data
        Complements

        Msp3003prime

        (Technau and Roth, 2008)

        Msp300sz75

        (Technau and Roth, 2008)
        Comments

        A Dp(2;1)B19 background rescues the lethality of Msp-3005prime mutants.

        (Technau and Roth, 2008)
        Images (0)
        Mutant
        Wild-type
        Stocks (0)
        Notes on Origin
        Discoverer
        External Crossreferences and Linkouts ( 0 )
        Synonyms and Secondary IDs (4)
        Reported As
        Symbol Synonym
        Df(2L)Msp-300-5
        (Technau and Roth, 2008)
        Msp-3005prime
        Msp3005prime
        Msp300Δ5'
        (Morton et al., 2025)
        Name Synonyms
        Secondary FlyBase IDs
          References (2)