FB2026_01 , released March 12, 2026
FB2026_01 , released March 12, 2026
Allele: Dmel\Tango12L3443
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General Information
Symbol
Dmel\Tango12L3443
Species
D. melanogaster
Name
FlyBase ID
FBal0218428
Feature type
allele
Associated gene
Dmel\Tango1
Associated Insertion(s)
Carried in Construct
Key Links
Genomic Maps

Allele class
Mutagen
Nature of the Allele
Allele class
Mutagen
ethyl methanesulfonate
(Baer et al., 2007)
Progenitor genotype
Cytology
Description

Amino acid replacement: R1341term.

(Ríos-Barrera et al., 2017)
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
point_mutation
2L:6,654,061..6,654,061 [+]
Nucleotide change:

C6654061T

Amino acid change:

R1341term | Tango1-PA; R1341term | Tango1-PC; R1335term | Tango1-PD

Reported amino acid change:

R1341term

Comment:

Site of nucleotide substitution in mutant inferred by FlyBase curator based on reported amino acid change.

(Ríos-Barrera et al., 2017)
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      Tango12L3443 tracheal terminal cell clones show air-filling defects and reduced branch numbers. Clonal terminal cells show abnormal ER, namely abnormal/enlarged ER exit sites (identified by Sec16 staining), as compared to controls.

      (Ríos-Barrera et al., 2017)

      Homozygous clones induced at the late blastoderm/early gastrulation stage and then examined in the third larval instar tracheal system result in defects in terminal branching.

      (Baer et al., 2007)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      Additional Comments
      Genetic Interactions
      Statement
      Reference
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer
      Comments
      Comments

      2L34432L3443 falls into lethal complementation group "E3".

      (Baer et al., 2007)
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (4)
      Reported As
      Symbol Synonym
      2L3443
      (Baer et al., 2007)
      2L34432L3443
      Tango12L3443
      tango12L3443
      (Ríos-Barrera et al., 2017)
      Name Synonyms
      Secondary FlyBase IDs
        References (2)