FB2026_01 , released March 12, 2026
FB2026_01 , released March 12, 2026
Allele: Dmel\PknΔC2.hs
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General Information
Symbol
Dmel\PknΔC2.hs
Species
D. melanogaster
Name
FlyBase ID
FBal0218998
Feature type
allele
Associated gene
Dmel\Pkn
Associated Insertion(s)
Carried in Construct
P{hs-Pkn.ΔC2}
Key Links
Transgenic product class
inframe_deletion
(Betson and Settleman, 2007)
Mutagen
Nature of the Allele
Transgenic product class
inframe_deletion
(Betson and Settleman, 2007)
Mutagen
in vitro construct
(Betson and Settleman, 2007)
Progenitor genotype
Carried in construct
P{hs-Pkn.ΔC2}
Cytology
Description

A heat shock promoter drives expression of a mutant form of Pkn, which lacks the C2 domain.

(Betson and Settleman, 2007)
Allele components
Component
Use(s)
Regulatory region(s)
Hsp70
Encoded product / tool
Pkn
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      Additional Comments
      Genetic Interactions
      Statement
      Reference
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Partially rescues

      PknΔC2.hs partially rescues Pkn06736

      (Betson and Settleman, 2007)
      Comments

      Expression of PknΔC2.hs using heat shock can rescue the lethality of Pkn06736 flies (the degree of rescue depends on the insertion line used).

      (Betson and Settleman, 2007)
      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (1)
      Reported As
      Symbol Synonym
      PknΔC2.hs
      Name Synonyms
      Secondary FlyBase IDs
        References (1)