FB2026_02 , released June 18, 2026
FB2026_02 , released June 18, 2026
Allele: Dmel\cadRNAi.397.UAS
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General Information
Symbol
Dmel\cadRNAi.397.UAS
Species
D. melanogaster
Name
FlyBase ID
FBal0219070
Feature type
allele
Associated gene
Dmel\cad
Associated Insertion(s)
Carried in Construct
P{UAS-cad.397.RNAi}
Key Links
Transgenic product class
RNAi_reagent
(Ryu et al., 2008)
Mutagen
Nature of the Allele
Transgenic product class
RNAi_reagent
(Ryu et al., 2008)
Mutagen
in vitro construct
(Ryu et al., 2008)
Progenitor genotype
Carried in construct
P{UAS-cad.397.RNAi}
Cytology
Description

UAS regulatory sequences drive expression of sequences designed to produce RNAi against cad.

(Ryu et al., 2008)
Allele components
Component
Use(s)
Regulatory region(s)
UAS
Encoded product / tool
cad
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      Expression of caddsRNA.397.UAS under the control of Scer\GAL4NP0001, in combination with a Gal80[ts] transgene to restrict expression to the adult stage, reduces lifespan, compared to controls.

      (Buchon et al., 2013)

      Flies expressing caddsRNA.Scer\UAS under the control of one of Scer\GAL4da.G32, Scer\GAL4cad-em459 or Scer\GAL4c729 show gut epithelial cell apoptosis at day 18 after eclosion (this cell death is not seen in control flies of the same age). The commensal bacterial population in the intestine is altered compared to wild type in these flies.

      Flies expressing caddsRNA.Scer\UAS under the control of Scer\GAL4c729 show reduced survival rates over time compared to control flies.

      Flies expressing caddsRNA.Scer\UAS under the control of Scer\GAL4c729 do not show gut epithelial cell apoptosis and show normal survival levels if they have been treated to make them germ-free.

      (Ryu et al., 2008)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      Additional Comments
      Genetic Interactions
      Statement
      Reference
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Rescued by

      cadRNAi.397.UAS is rescued by Scer\GAL4c729/cadUAS.cRa

      (Ryu et al., 2008)
      Comments
      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (4)
      Reported As
      Symbol Synonym
      cadRNAi.397.UAS
      caddsRNA.397.Scer\UAS
      caddsRNA.397.UAS
      caddsRNA.Scer\UAS
      Name Synonyms
      Secondary FlyBase IDs
        References (3)