FlyBase Allele Report: Dmel\Stam[2L3297]

General Information

Symbol

Dmel\Stam^2L3297

Species

D. melanogaster

Name

FlyBase ID

FBal0219180

Feature type

allele

Associated gene

Dmel\Stam

Associated Insertion(s)

Carried in Construct

Key Links

Genomic Maps

JBrowse

Allele class

Mutagen

ethyl methanesulfonate

Nature of the Allele

Allele class

Mutagen

ethyl methanesulfonate

(Chanut-Delalande et al., 2007)

Progenitor genotype

Cytology

Description

Amino acid replacement: F428S.

(Chanut-Delalande et al., 2007)

Nucleotide substitution: T1283C.

(Chanut-Delalande et al., 2007)

Amino acid replacement: Y528H.

(Chanut-Delalande et al., 2007)

Nucleotide substitution: T1583C.

(Chanut-Delalande et al., 2007)

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

point_mutation

2L:10,860,668..10,860,668 [+]

Nucleotide change:

T10860668C

Reported nucleotide change:

T1283C

Amino acid change:

F428S | Stam-PA

Reported amino acid change:

F428S

(Chanut-Delalande et al., 2007)

point_mutation

2L:10,861,033..10,861,033 [+]

Nucleotide change:

T10861033C

Reported nucleotide change:

T1583C

Amino acid change:

Y528H | Stam-PA

Reported amino acid change:

Y528H

(Chanut-Delalande et al., 2007)

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

increased cell death | somatic clone | third instar larval stage

(Sheng et al., 2016)

lethal | recessive

(Chanut-Delalande et al., 2007)

Phenotype Manifest In

dorsal air sac primordium | somatic clone

(Chanut-Delalande et al., 2007)

eye disc | somatic clone | third instar larval stage

(Sheng et al., 2016)

wing disc | somatic clone | third instar larval stage

(Sheng et al., 2016)

Detailed Description

Statement

Reference

Somatic clones of Stam^2L3297/Stam^2L3297 cells in the third instar larval eye or wing disc display low levels of apoptosis (detected by Caspase-3 staining).

(Sheng et al., 2016)

Homozygous clones show defects in tracheal cell migration during morphogenesis of the dorsal air sac primordium; less than 40% of clones reach the distal tip of the primordium.

(Chanut-Delalande et al., 2007)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Enhanced by

Statement

Reference

Stam^2L3297 has increased cell death | third instar larval stage | somatic clone phenotype, enhanceable by Rbf^15aΔ/Rbf^15aΔ

(Sheng et al., 2016)

Enhancer of

Statement

Reference

Stam^2L3297/Stam^2L3297 is an enhancer of increased cell death | third instar larval stage | somatic clone phenotype of Rbf^15aΔ

(Sheng et al., 2016)

Phenotype Manifest In

Enhanced by

Statement

Reference

Stam^2L3297 has eye disc | third instar larval stage | somatic clone phenotype, enhanceable by Rbf^15aΔ/Rbf^15aΔ

(Sheng et al., 2016)

Stam^2L3297 has wing disc | third instar larval stage | somatic clone phenotype, enhanceable by Rbf^15aΔ/Rbf^15aΔ

(Sheng et al., 2016)

Enhancer of

Statement

Reference

Stam^2L3297/Stam^2L3297 is an enhancer of eye disc | third instar larval stage | somatic clone phenotype of Rbf^15aΔ

(Sheng et al., 2016)

Stam^2L3297/Stam^2L3297 is an enhancer of wing disc | third instar larval stage | somatic clone phenotype of Rbf^15aΔ

(Sheng et al., 2016)

Additional Comments

Genetic Interactions

Statement

Reference

Somatic clones of Rbf^15aΔ;Stam^2L3297 double homozygous cells display significantly higher levels of apoptosis in third instar larval wing and eye discs, even in clones posterior to the eye disc morphogenetic furrow, compared to clones homozygous for either Rbf^15aΔ or Stam^2L3297 alone.

(Sheng et al., 2016)

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Fails to complement

Stam^2L2896

(Chanut-Delalande et al., 2007)

Rescued by

Stam^2L3297 is rescued by Stam^UAS.cCDa/Scer\GAL4^btl.PS

(Chanut-Delalande et al., 2007)

Comments

Images (0)

Mutant

Wild-type

Stocks (1)

Bloomington

41805

Stam^2L3297 P{neoFRT}40A/CyO, P{ftz-lacB}E3

Notes on Origin

Discoverer

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (4)

Reported As

Symbol Synonym

2L 3297

(Chanut-Delalande et al., 2007)

STAM^2L3297

(Du et al., 2011)

Stam^2L3297

stam³²⁹⁷

(Sheng et al., 2016)

Name Synonyms

Secondary FlyBase IDs

References (3)

Report Sections

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