The survival rate of flies expressing Hsap\HDQ48.ex1p.Scer\UAS in the nervous system (under the regulation of Scer\GAL4elav-C155) is enhanced by the addition of CrebB-17A+tIa, leading to a survival rate of just over 20% (compared to approximately 15%). Addition of a heterozygous CrebB-17AS162 background to CrebB-17A+tIa Hsap\HDQ48.ex1p.Scer\UAS (Scer\GAL4elav-C155) flies reduces the survival rate slightly, although lethality is not as high as in Hsap\HDQ48.ex1p.Scer\UAS (Scer\GAL4elav-C155) flies.
Expression of Hsc70-4K71S.Scer\UAS in flies expressing Hsap\HDQ108.ex1p.Scer\UAS under the control of Scer\GAL4elav-C155 in a CrebB-17A+tIa transgene background increases the survival rate from approximately 10% in Hsap\HDQ108.ex1p.Scer\UAS (Scer\GAL4elav-C155) CrebB-17A+tIa mutants, to over 100%, indicating a synergistic effect between Hsc70-4K71S.Scer\UAS and CrebB-17A+tIa.
CrebB-17A+tIa and Hsc70-4K71S.Scer\UAS transgenes additively suppress Hsap\HDQ108.ex1p.Scer\UAS-mediated locomotor dysfunction (under the control of Scer\GAL4elav-C155). This suppression is more dramatic as the flies age.