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General Information
Symbol
Dmel\CrebB+tIa
Species
D. melanogaster
Name
FlyBase ID
FBal0219579
Feature type
allele
Associated gene
Associated Insertion(s)
Carried in Construct
Key Links
Allele class
Nature of the Allele
Allele class
Mutations Mapped to the Genome
 
Type
Location
Additional Notes
References
Associated Sequence Data
DNA sequence
Protein sequence
 
 
Progenitor genotype
Carried in construct
Cytology
Nature of the lesion
Statement
Reference

A ~9kb genomic fragment containing the CrebB-17A region.

Allele components
Product class / Tool use(s)
Regulatory region(s)
Encoded product / tool
Expression Data
Reporter Expression
Additional Information
Statement
Reference
 
Marker for
Reflects expression of
Reporter construct used in assay
Human Disease Associations
Disease Ontology (DO) Annotations
Models Based on Experimental Evidence ( 0 )
Disease
Evidence
References
Modifiers Based on Experimental Evidence ( 1 )
Disease
Interaction
References
Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
 
Disease-implicated variant(s)
 
Phenotypic Data
Phenotypic Class
Phenotype Manifest In
Detailed Description
Statement
Reference
External Data
Interactions
Show genetic interaction network for Enhancers & Suppressors
Phenotypic Class
Phenotype Manifest In
Additional Comments
Genetic Interactions
Statement
Reference
Xenogenetic Interactions
Statement
Reference

The survival rate of flies expressing Hsap\HDQ48.ex1p.Scer\UAS in the nervous system (under the regulation of Scer\GAL4elav-C155) is enhanced by the addition of CrebB-17A+tIa, leading to a survival rate of just over 20% (compared to approximately 15%). Addition of a heterozygous CrebB-17AS162 background to CrebB-17A+tIa Hsap\HDQ48.ex1p.Scer\UAS (Scer\GAL4elav-C155) flies reduces the survival rate slightly, although lethality is not as high as in Hsap\HDQ48.ex1p.Scer\UAS (Scer\GAL4elav-C155) flies.

Expression of Hsc70-4K71S.Scer\UAS in flies expressing Hsap\HDQ108.ex1p.Scer\UAS under the control of Scer\GAL4elav-C155 in a CrebB-17A+tIa transgene background increases the survival rate from approximately 10% in Hsap\HDQ108.ex1p.Scer\UAS (Scer\GAL4elav-C155) CrebB-17A+tIa mutants, to over 100%, indicating a synergistic effect between Hsc70-4K71S.Scer\UAS and CrebB-17A+tIa.

The presence of the CrebB-17A+tIa transgene does not suppress Hsap\HDQ108.ex1p.Scer\UAS-mediated locomotor dysfunction.

CrebB-17A+tIa and Hsc70-4K71S.Scer\UAS transgenes additively suppress Hsap\HDQ108.ex1p.Scer\UAS-mediated locomotor dysfunction (under the control of Scer\GAL4elav-C155). This suppression is more dramatic as the flies age.

Complementation and Rescue Data
Images (0)
Mutant
Wild-type
Stocks (0)
Notes on Origin
Discoverer
External Crossreferences and Linkouts ( 0 )
Synonyms and Secondary IDs (2)
Reported As
Symbol Synonym
CrebB-17A+tIa
CrebB+tIa
Name Synonyms
Secondary FlyBase IDs
    References (1)