FB2026_01 , released March 12, 2026
FB2026_01 , released March 12, 2026
Allele: Dmel\CrebB+tIa
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General Information
Symbol
Dmel\CrebB+tIa
Species
D. melanogaster
Name
FlyBase ID
FBal0219579
Feature type
allele
Associated gene
Dmel\CrebB
Associated Insertion(s)
Carried in Construct
P{gdCREB.I}
Key Links
Transgenic product class
genomic_DNA
(Iijima-Ando et al., 2005)
wild_type
(Iijima-Ando et al., 2005)
Mutagen
Nature of the Allele
Transgenic product class
genomic_DNA
(Iijima-Ando et al., 2005)
wild_type
(Iijima-Ando et al., 2005)
Mutagen
in vitro construct
(Iijima-Ando et al., 2005)
Progenitor genotype
Carried in construct
P{gdCREB.I}
Cytology
Description

A ~9kb genomic fragment containing the CrebB-17A region.

(Iijima-Ando et al., 2005)
Allele components
Component
Use(s)
Regulatory region(s)
CrebB
Encoded product / tool
CrebB
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 1 )
      Disease
      Interaction
      References
      ameliorates  Huntington's disease
      modeled by Hsap\HTTQ48.ex1p.UAS, Hsc70-4K71S.UAS
      (Iijima-Ando et al., 2005)
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      Additional Comments
      Genetic Interactions
      Statement
      Reference
      Xenogenetic Interactions
      Statement
      Reference

      The survival rate of flies expressing Hsap\HDQ48.ex1p.Scer\UAS in the nervous system (under the regulation of Scer\GAL4elav-C155) is enhanced by the addition of CrebB-17A+tIa, leading to a survival rate of just over 20% (compared to approximately 15%). Addition of a heterozygous CrebB-17AS162 background to CrebB-17A+tIa Hsap\HDQ48.ex1p.Scer\UAS (Scer\GAL4elav-C155) flies reduces the survival rate slightly, although lethality is not as high as in Hsap\HDQ48.ex1p.Scer\UAS (Scer\GAL4elav-C155) flies.

      Expression of Hsc70-4K71S.Scer\UAS in flies expressing Hsap\HDQ108.ex1p.Scer\UAS under the control of Scer\GAL4elav-C155 in a CrebB-17A+tIa transgene background increases the survival rate from approximately 10% in Hsap\HDQ108.ex1p.Scer\UAS (Scer\GAL4elav-C155) CrebB-17A+tIa mutants, to over 100%, indicating a synergistic effect between Hsc70-4K71S.Scer\UAS and CrebB-17A+tIa.

      The presence of the CrebB-17A+tIa transgene does not suppress Hsap\HDQ108.ex1p.Scer\UAS-mediated locomotor dysfunction.

      CrebB-17A+tIa and Hsc70-4K71S.Scer\UAS transgenes additively suppress Hsap\HDQ108.ex1p.Scer\UAS-mediated locomotor dysfunction (under the control of Scer\GAL4elav-C155). This suppression is more dramatic as the flies age.

      (Iijima-Ando et al., 2005)
      Complementation and Rescue Data
      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (2)
      Reported As
      Symbol Synonym
      CrebB-17A+tIa
      CrebB+tIa
      Name Synonyms
      Secondary FlyBase IDs
        References (1)