FB2026_01 , released March 12, 2026
FB2026_01 , released March 12, 2026
Allele: Dmel\CrebB+t.STOP
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General Information
Symbol
Dmel\CrebB+t.STOP
Species
D. melanogaster
Name
FlyBase ID
FBal0219580
Feature type
allele
Associated gene
Dmel\CrebB
Associated Insertion(s)
Carried in Construct
P{UAS-gdCREB.STOP}
Key Links
Transgenic product class
stop_gained
(Iijima-Ando et al., 2005)
Mutagen
Nature of the Allele
Transgenic product class
stop_gained
(Iijima-Ando et al., 2005)
Mutagen
in vitro construct
(Iijima-Ando et al., 2005)
Progenitor genotype
Carried in construct
P{UAS-gdCREB.STOP}
Cytology
Description

A ~9kb genomic fragment containing the CrebB-17A region, engineered to contain a stop codon in the coding region (in the 5th exon).

(Iijima-Ando et al., 2005)
Allele components
Component
Use(s)
Encoded product / tool
CrebB
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      NOT Suppressor of
      Phenotype Manifest In
      Additional Comments
      Genetic Interactions
      Statement
      Reference
      Xenogenetic Interactions
      Statement
      Reference

      Addition of the CrebB-17A+t.STOP transgene to flies expressing Hsap\HDQ48.ex1p.Scer\UAS under the control of Scer\GAL4elav-C155 results in a reduction in survival rate of about 2%.

      Addition of the CrebB-17A+t.STOP transgene to homozygous CrebB-17AS162 flies expressing Hsap\HDQ48.ex1p.Scer\UAS under the control of Scer\GAL4elav-C155 results in an approximate 1% survival rate.

      (Iijima-Ando et al., 2005)
      Complementation and Rescue Data
      Fails to rescue

      CrebB+t.STOP fails to rescue CrebBS162

      (Iijima-Ando et al., 2005)
      Comments
      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (2)
      Reported As
      Symbol Synonym
      CrebB-17A+t.STOP
      CrebB+t.STOP
      Name Synonyms
      Secondary FlyBase IDs
        References (1)