FB2026_01 , released March 12, 2026
FB2026_01 , released March 12, 2026
Allele: Dmel\trbl3-54
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General Information
Symbol
Dmel\trbl3-54
Species
D. melanogaster
Name
FlyBase ID
FBal0220156
Feature type
allele
Associated gene
Dmel\trbl
Associated Insertion(s)
P{GawB}trbl3-54
Carried in Construct
Key Links
Allele class

loss of function allele

Mutagen
    Nature of the Allele
    Allele class

    loss of function allele

    (LaFerriere and Zars, 2017)
    Mutagen
    Progenitor genotype
    Associated Insertion(s)
    P{GawB}trbl3-54
    Cytology
    Description

    Insertion approximately 250bp 5' of trbl exon 1.

    (LaFerriere et al., 2008)
    Allele components
    Component
    Use(s)
    Inserted element
    P{GawB}
    Encoded product / tool
    GAL4
    Mutations Mapped to the Genome
    Curation Data
    Type
    Location
    Additional Notes
    References
    Variant Molecular Consequences
    Associated Sequence Data
    DDBJ / EMBL / GenBank
    DNA sequence
    Protein sequence
     
    UniProtKB/Swiss-Prot
      UniProtKB/TrEMBL
        Expression Data
        Reporter Expression
        Additional Information
        Statement
        Reference
         
        Marker for
        Reflects expression of
        Reporter construct used in assay
        Human Disease Associations
        Disease Ontology (DO) Annotations
        Models Based on Experimental Evidence ( 0 )
        Disease
        Evidence
        References
        Modifiers Based on Experimental Evidence ( 0 )
        Disease
        Interaction
        References
        Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
         
        Disease-implicated variant(s)
         
        Phenotypic Data
        Phenotypic Class
        Phenotype Manifest In
        Detailed Description
        Statement
        Reference

        Mutant flies show normal sensitivity to ethanol in an inebriometer assay.

        The memory score of mutant flies in the heat-box place-learning paradigm is significantly reduced compared to that of control flies. The mutant flies show no difference from control flies in their ability to avoid a high-temperature source when allowed to choose between chamber halves that are either at 24[o] or 42[o]C.

        Mutant flies have a significantly higher memory score than that of control flies in an olfactory conditioning assay. The memory of mutant flies remains elevated relative to wild-type performance even 3 hours after training.

        Mutant flies show a normal response response to each of the odours 4-methylcyclohexanol and octanol in an olfactory avoidance assay.

        Reactivity to electric shock in mutant flies is not significantly different from that of control flies.

        (LaFerriere et al., 2008)
        External Data
        Interactions
        Show genetic interaction network for Enhancers & Suppressors
        Phenotypic Class
        Phenotype Manifest In
        Additional Comments
        Genetic Interactions
        Statement
        Reference
        Xenogenetic Interactions
        Statement
        Reference
        Complementation and Rescue Data
        Comments
        Images (0)
        Mutant
        Wild-type
        Stocks (0)
        Notes on Origin
        Discoverer
        External Crossreferences and Linkouts ( 0 )
        Synonyms and Secondary IDs (2)
        Reported As
        Symbol Synonym
        3-54
        (LaFerriere et al., 2008)
        trbl3-54
        (LaFerriere and Zars, 2017)
        Name Synonyms
        Secondary FlyBase IDs
          References (2)