FB2026_02 , released June 18, 2026
Allele: Dmel\appe6
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General Information
Symbol
Dmel\appe6
Species
D. melanogaster
Name
FlyBase ID
FBal0220521
Feature type
allele
Associated gene
Dmel\app
Associated Insertion(s)
Carried in Construct
Key Links
Genomic Maps

Allele class

amorphic allele - genetic evidence

Mutagen
Nature of the Allele
Allele class

amorphic allele - genetic evidence

(Matakatsu and Blair, 2008)
Mutagen
ethyl methanesulfonate
(Matakatsu and Blair, 2008)
Progenitor genotype
Cytology
Description

Amino acid replacement: R104term.

(Matakatsu and Blair, 2008)
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
point_mutation
3L:12,216,461..12,216,461 [-]
Nucleotide change:

C12216461T

Amino acid change:

R104term | app-PH; R104term | app-PI; R104term | app-PJ; R104term | app-PK; R104term | app-PL; R104term | app-PM; R104term | app-PO; R104term | app-PR; R104term | app-PT

Reported amino acid change:

R104term

Comment:

Site of nucleotide substitution in mutant inferred by FlyBase based on reported amino acid change.

(Matakatsu and Blair, 2008)
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      Adult escapers have extensive wing planar cell polarity (PCP) defects, both proximally and in a distal region between the third and fourth wing veins.

      appe6/Df(3L)ED4475 animals have planar cell polarity defects in the wing and also in the abdomen where polarity is disturbed around the anterior-posterior boundary and is extensively reversed in the posterior compartment.

      Small to moderately size homozygous clones in the wing do not affect PCP, while large clones only affect PCP in the regions of the wing where PCP defects are seen in homozygous flies. There is no tendency to reorient hairs at clone boundaries.

      (Matakatsu and Blair, 2008)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Suppressed by
      Suppressor of
      Statement
      Reference

      appe6 is a suppressor | partially of lethal | pupal stage phenotype of ft8/ftG-rv

      (Matakatsu and Blair, 2008)

      appe6 is a suppressor | partially of abnormal planar polarity | pupal stage phenotype of ft8/ftG-rv

      (Matakatsu and Blair, 2008)
      Phenotype Manifest In
      Suppressor of
      Statement
      Reference

      appe6 is a suppressor of wing disc | pupal stage phenotype of ft8/ftG-rv

      (Matakatsu and Blair, 2008)

      appe6 is a suppressor of eye disc | pupal stage phenotype of ft8/ftG-rv

      (Matakatsu and Blair, 2008)

      appe6 is a suppressor | partially of abdomen | pupal stage phenotype of ft8/ftG-rv

      (Matakatsu and Blair, 2008)
      Other
      Statement
      Reference

      appe6, ft8/ftG-rv has wing hair phenotype

      (Matakatsu and Blair, 2008)
      Additional Comments
      Genetic Interactions
      Statement
      Reference

      The disc overgrowth phenotypes of ft8/ftG-rv pupae are suppressed by appe6 and the abdominal planar cell polarity (PCP) and lethality phenotypes are reduced in the double mutants compared to the ft8/ftG-rv single mutant. The double mutant adults have PCP defects in proximal portions of the wing, but not in the distal wing.

      The PCP defects that are seen between distal veins L4 and L5 in appe6 mutants are rescued on the dorsal surface by expression of dScer\UAS.T:SV5\V5,T:Zzzz\His6 under the control of Scer\GAL4ap-md544.

      (Matakatsu and Blair, 2008)
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Fails to complement

      app1

      (Matakatsu and Blair, 2008)
      Rescued by

      appe6 is rescued by Scer\GAL4Act.PU/appRA.UAS

      (Matakatsu and Blair, 2008)
      Comments
      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (1)
      Reported As
      Symbol Synonym
      appe6
      (Matakatsu et al., 2017, Matakatsu and Blair, 2008)
      Name Synonyms
      Secondary FlyBase IDs
        References (2)