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General Information
Symbol
Dmel\lolaJF02254
Species
D. melanogaster
Name
FlyBase ID
FBal0220646
Feature type
allele
Associated gene
Associated Insertion(s)
Carried in Construct
Key Links
Allele class
Nature of the Allele
Allele class
Mutations Mapped to the Genome
 
Type
Location
Additional Notes
References
Associated Sequence Data
DNA sequence
Protein sequence
 
 
Progenitor genotype
Carried in construct
Cytology
Nature of the lesion
Statement
Reference

UAS regulatory sequences drive expression of an inverted repeat.

Allele components
Product class / Tool use(s)
Encoded product / tool
Associated Sequence Features
Expression Data
Reporter Expression
Additional Information
Statement
Reference
 
Marker for
Reflects expression of
Reporter construct used in assay
Human Disease Associations
Disease Ontology (DO) Annotations
Models Based on Experimental Evidence ( 0 )
Disease
Evidence
References
Modifiers Based on Experimental Evidence ( 0 )
Disease
Interaction
References
Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
 
Disease-implicated variant(s)
 
Phenotypic Data
Phenotypic Class
Phenotype Manifest In
Detailed Description
Statement
Reference

Expression of lolaJF02254 driven by Scer\GAL4GMR.PU does not significantly affect eye morphology.

Expression of lolaJF02254 in muscle under the control of Scer\GAL4Mef2.PU results in significant hyperglycaemia.

Expression of lolaJF02254 in the fat body under the control of Scer\GAL4DcG results in significant hyperglycaemia.

Expression of lolaJF02254 in the fat body under the control of Scer\GAL4DcG results in significant higher trehalose levels than controls.

Only 50% of males expressing lolaJF02254 under the control of Scer\GAL4fru.P1.D initiate courtship behaviour towards wild-type females during a 1 hour observation period, and those that do court show a significant delay.

The expression of lolaJF02254 under the control of Scer\GAL4221, in combination with Dicer-2 for efficient RNAi, results in third instar larval class I abdominal dorsal multidendritic neurons ddaD and ddaE exhibiting a significant decrease in the number of dendrite branch terminals, as compared to controls.

Expressing lolaJF02254 under the control of Scer\GAL4ppk.PG, in combination with Dicer-2 for efficient RNAi, results in third intar larval class IV abdominal dorsal multidendritic neurons ddaC exhibiting dendrite branch terminals of similar number but of significantly lower average length, as compared to controls.

Expression of lolaJF02254 in C-I neurons under the control of Scer\GAL4221 results in ddaD neurons that have an increased number of dendritic branches compared to controls. Dendritic phenotypes are also seen in ddaE neurons. No defects are seen in vpda neurons.

Expression of lolaJF02254 in C-IV neurons under the control of Scer\GAL4ppk.1.9 results in a reduction in total dendritic length in ddaC, v'ada and vdaB neurons. The total number of dendritic branches is also reduced in ddaC and vdaB neurons.

External Data
Interactions
Show genetic interaction network for Enhancers & Suppressors
Phenotypic Class
Suppressor of
Statement
Reference
Phenotype Manifest In
Suppressor of
Statement
Reference
Additional Comments
Genetic Interactions
Statement
Reference

Co-expression of lolaJF02254 suppresses the rough eye phenotype in flies with forGD6843 driven by Scer\GAL4GMR.PU. Expression of lolaJF02254 driven by Scer\GAL4elav.PU partially suppresses targeting defects seen in motor axons of intersegmental nerve b (ISNb) in Df(2L)ED243/Df(2L)ED243 mutant embryos.

Xenogenetic Interactions
Statement
Reference
Complementation and Rescue Data
Comments
Images (0)
Mutant
Wild-type
Stocks (1)
Notes on Origin
Discoverer
External Crossreferences and Linkouts ( 0 )
Synonyms and Secondary IDs (1)
Reported As
Symbol Synonym
lolaJF02254
Name Synonyms
Secondary FlyBase IDs
    References (8)