FlyBase Allele Report: Dmel\pros[JF02308]

General Information

Symbol

Dmel\pros^JF02308

Species

D. melanogaster

Name

FlyBase ID

FBal0220677

Feature type

allele

Associated gene

Dmel\pros

Associated Insertion(s)

Carried in Construct

P{TRiP.JF02308}

Also Known As

UAS-pros RNAi, UAS-pros^RNAi, JF02308, UAS-pros-RNAi

Key Links

Genomic Maps

JBrowse

Transgenic product class

RNAi_reagent

(Perkins et al., 2009.3.31)

Mutagen

in vitro construct

Nature of the Allele

Transgenic product class

RNAi_reagent

(Perkins et al., 2009.3.31)

Mutagen

in vitro construct

(Perkins et al., 2009.3.31)

Progenitor genotype

Carried in construct

P{TRiP.JF02308}

Cytology

Description

UAS regulatory sequences drive expression of an inverted repeat.

(Perkins et al., 2009.3.31)

Allele components

Component

Use(s)

Regulatory region(s)

UAS

binary expression system - regulatory region

Encoded product / tool

dsRNA-JF02308

Also carries

loxP

recombinase target site

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 1 )

Disease

Evidence

References

model of brain cancer

CEA

(Gaultier et al., 2022, Narbonne-Reveau et al., 2016)

Modifiers Based on Experimental Evidence ( 1 )

Disease

Interaction

References

model of brain cancer

is ameliorated by E(z)^KK102729

(Gaultier et al., 2022)

is ameliorated by Hsap\H3-3A^{K27M.UAS.Tag:FLAG,Tag:HA}

(Gaultier et al., 2022)

is ameliorated by Psc^JF01395

(Gaultier et al., 2022)

is ameliorated by Set1^HMS00581

(Gaultier et al., 2022)

is ameliorated by Su(z)12^JF01706

(Gaultier et al., 2022)

is ameliorated by abd-A^UAS.Tag:HA

(Gaultier et al., 2022)

is exacerbated by cas^UAS.cKa

(Gaultier et al., 2022)

is ameliorated by E(z)^JF02826

(Gaultier et al., 2022)

is exacerbated by esc^GD1240

(Gaultier et al., 2022)

is ameliorated by trr^JF03242

(Gaultier et al., 2022)

is ameliorated by trx^KK100756

(Gaultier et al., 2022)

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

abnormal cell number, with Scer\GAL4^GMR56F03

(Casas-Tinto et al., 2025)

decreased size | P-stage | somatic clone, with Scer\GAL4^Tub.PU

(Nguyen and Cheng, 2024)

flightless, with Scer\GAL4^Mef2.PR

(Katti et al., 2022)

increased cell number | larval stage | somatic clone, with Scer\GAL4^Tub.PU

(Nguyen and Cheng, 2024)

increased cell number | P-stage | somatic clone, with Scer\GAL4^Tub.PU

(Nguyen and Cheng, 2024)

lethal, with Scer\GAL4^Mef2.PR

(Katti et al., 2022)

Phenotype Manifest In

central nervous system, with Scer\GAL4^GMR56F03

(Casas-Tinto et al., 2025)

optic neuroblast | ectopic | larval stage | somatic clone, with Scer\GAL4^Tub.PU

(Nguyen and Cheng, 2024)

optic neuroblast | P-stage | increased number | somatic clone, with Scer\GAL4^Tub.PU

(Nguyen and Cheng, 2024)

Detailed Description

Statement

Reference

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Suppressor of

Statement

Reference

pros^JF02308, Scer\GAL4^insc-Mz1407 is a suppressor of abnormal cell number | third instar larval stage phenotype of CkIIβ^NIG.15224R, Scer\GAL4^insc-Mz1407

(Zhang et al., 2026)

pros^JF02308, Scer\GAL4^insc-Mz1407 is a suppressor of abnormal cell number | third instar larval stage phenotype of CkIIα^NIG.17520R, Scer\GAL4^insc-Mz1407

(Zhang et al., 2026)

Phenotype Manifest In

Suppressor of

Statement

Reference

pros^JF02308, Scer\GAL4^insc-Mz1407 is a suppressor of larval neuroblast | third instar larval stage phenotype of CkIIβ^NIG.15224R, Scer\GAL4^insc-Mz1407

(Zhang et al., 2026)

pros^JF02308, Scer\GAL4^insc-Mz1407 is a suppressor of larval central brain | third instar larval stage phenotype of CkIIβ^NIG.15224R, Scer\GAL4^insc-Mz1407

(Zhang et al., 2026)

pros^JF02308, Scer\GAL4^insc-Mz1407 is a suppressor of larval neuroblast | third instar larval stage phenotype of CkIIα^NIG.17520R, Scer\GAL4^insc-Mz1407

(Zhang et al., 2026)

pros^JF02308, Scer\GAL4^insc-Mz1407 is a suppressor of larval central brain | third instar larval stage phenotype of CkIIα^NIG.17520R, Scer\GAL4^insc-Mz1407

(Zhang et al., 2026)

Additional Comments

Genetic Interactions

Statement

Reference

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Comments

Images (0)

Mutant

Wild-type

Stocks (1)

Bloomington

26745

y¹ v¹; P{TRiP.JF02308}attP2/TM3, Sb¹

Notes on Origin

Discoverer

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (1)

Reported As

Symbol Synonym

pros^JF02308

Name Synonyms

Secondary FlyBase IDs

References (19)

Report Sections

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