FlyBase Allele Report: Dmel\lab[JF02317]

General Information

Symbol

Dmel\lab^JF02317

Species

D. melanogaster

Name

FlyBase ID

FBal0220685

Feature type

allele

Associated gene

Dmel\lab

Associated Insertion(s)

Carried in Construct

P{TRiP.JF02317}

Key Links

Genomic Maps

JBrowse

Transgenic product class

RNAi_reagent

(Perkins et al., 2009.3.31)

Mutagen

in vitro construct

Nature of the Allele

Transgenic product class

RNAi_reagent

(Perkins et al., 2009.3.31)

Mutagen

in vitro construct

(Perkins et al., 2009.3.31)

Progenitor genotype

Carried in construct

P{TRiP.JF02317}

Cytology

Description

UAS regulatory sequences drive expression of an inverted repeat.

(Perkins et al., 2009.3.31)

Allele components

Component

Use(s)

Regulatory region(s)

UAS

binary expression system - regulatory region

Encoded product / tool

dsRNA-JF02317

Also carries

loxP

recombinase target site

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

abnormal cell shape | adult stage, with Scer\GAL4^NP0001

(Buchon et al., 2013)

decreased occurrence of cell division | conditional, with Scer\GAL4^NP3084

(Geng et al., 2025)

increased occurrence of cell division | adult stage, with Scer\GAL4^NP0001

(Buchon et al., 2013)

short lived, with Scer\GAL4^NP0001

(Buchon et al., 2013)

Phenotype Manifest In

adult copper cell, with Scer\GAL4^NP0001

(Buchon et al., 2013)

adult midgut, with Scer\GAL4^NP0001

(Buchon et al., 2013)

adult midgut enterocyte, with Scer\GAL4^NP0001

(Buchon et al., 2013)

adult midgut region R3, with Scer\GAL4^NP0001

(Buchon et al., 2013)

brush border | adult stage, with Scer\GAL4^NP0001

(Buchon et al., 2013)

eye, with Scer\GAL4^dpp.s-hc

(Stultz et al., 2012)

maxillary palp | somatic clone, with Scer\GAL4^dpp.s-hc

(Stultz et al., 2012)

midgut | conditional, with Scer\GAL4^NP3084

(Geng et al., 2025)

vibrissal bristle, with Scer\GAL4^dpp.s-hc

(Stultz et al., 2012)

Detailed Description

Statement

Reference

Expression of lab^JF02317 under the control of Scer\GAL4^NP0001, in combination with a Gal80[ts] transgene to restrict expression to the adult stage, results in the loss of the ring-shaped brush borders and invagination characteristic of copper cells; R3 enterocytes display a smoothed shape reminiscent of enterocytes found in R2 or R4; there is also an increase in cell division (PH3 staining) in the midgut and a reduction in lifespan, compared to controls.

(Buchon et al., 2013)

Expression of lab^JF02317 under the control of Scer\GAL4^dpp.s-hc produces head defects with severe eye reductions, vibrissae defects and loss of maxillary palps.

(Stultz et al., 2012)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Phenotype Manifest In

Additional Comments

Genetic Interactions

Statement

Reference

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Comments

Images (0)

Mutant

Wild-type

Stocks (1)

Bloomington

26753

y¹ v¹; P{TRiP.JF02317}attP2/TM3, Sb¹

Notes on Origin

Discoverer

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (1)

Reported As

Symbol Synonym

lab^JF02317

Name Synonyms

Secondary FlyBase IDs

References (6)

Report Sections

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