FlyBase Allele Report: Dmel\Ddc[JF02356]

General Information

Symbol

Dmel\Ddc^JF02356

Species

D. melanogaster

Name

FlyBase ID

FBal0220720

Feature type

allele

Associated gene

Dmel\Ddc

Associated Insertion(s)

Carried in Construct

P{TRiP.JF02356}

Also Known As

UAS-Ddc^RNAi, Ddc RNAi

Key Links

Genomic Maps

JBrowse

Transgenic product class

RNAi_reagent

(Perkins et al., 2009.3.31)

Mutagen

in vitro construct

Nature of the Allele

Transgenic product class

RNAi_reagent

(Perkins et al., 2009.3.31)

Mutagen

in vitro construct

(Perkins et al., 2009.3.31)

Progenitor genotype

Carried in construct

P{TRiP.JF02356}

Cytology

Description

UAS regulatory sequences drive expression of an inverted repeat.

(Perkins et al., 2009.3.31)

Allele components

Component

Use(s)

Regulatory region(s)

UAS

binary expression system - regulatory region

Encoded product / tool

dsRNA-JF02356

Also carries

loxP

recombinase target site

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

abnormal body color | adult stage, with Scer\GAL4^pnr-MD237

(Zhang et al., 2021)

Phenotype Manifest In

adult external abdomen, with Scer\GAL4^pnr-MD237

(Zhang et al., 2021)

adult external thorax, with Scer\GAL4^pnr-MD237

(Zhang et al., 2021)

Detailed Description

Statement

Reference

The expression of Ddc^JF02356 under the control of Scer\GAL4^pnr-MD237 induces hypopigmentation in the adult thorax and abdomen.

(Zhang et al., 2021)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Suppressor of

Statement

Reference

Ddc^JF02356, Scer\GAL4^pnr-MD237 is a suppressor of abnormal body color | adult stage phenotype of Rpn9^HMS05753, Scer\GAL4^pnr-MD237

(Zhang et al., 2021)

Ddc^JF02356, Scer\GAL4^pnr-MD237 is a suppressor of abnormal body color | adult stage phenotype of Scer\GAL4^pnr-MD237, Vhl^KK111257

(Zhang et al., 2021)

Other

Statement

Reference

Ddc^JF02356, Scer\GAL4^pnr-MD237, Vhl^KK111257 has lethal phenotype

(Zhang et al., 2021)

Phenotype Manifest In

Suppressor of

Statement

Reference

Ddc^JF02356, Scer\GAL4^pnr-MD237 is a suppressor of adult external thorax phenotype of Rpn9^HMS05753, Scer\GAL4^pnr-MD237

(Zhang et al., 2021)

Ddc^JF02356, Scer\GAL4^pnr-MD237 is a suppressor of adult external thorax phenotype of Scer\GAL4^pnr-MD237, Vhl^KK111257

(Zhang et al., 2021)

Additional Comments

Genetic Interactions

Statement

Reference

The co-expression of Vhl^KK111257 and Ddc^JF02356 under the control of Scer\GAL4^pnr-MD237 at high levels leads to lethality. At lower levels, it suppresses the thoracic hyperpigmentation generated by the expression of Vhl^KK111257 alone.

(Zhang et al., 2021)

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Comments

Images (0)

Mutant

Wild-type

Stocks (1)

Bloomington

27030

y¹ v¹; P{TRiP.JF02356}attP2

Notes on Origin

Discoverer

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (1)

Reported As

Symbol Synonym

Ddc^JF02356

Name Synonyms

Secondary FlyBase IDs

References (7)

Report Sections

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