FlyBase Allele Report: Dmel\Vhl[KK111257]

General Information

Symbol

Dmel\Vhl^KK111257

Species

D. melanogaster

Name

FlyBase ID

FBal0237303

Feature type

allele

Associated gene

Dmel\Vhl

Associated Insertion(s)

Carried in Construct

P{KK111257}

Also Known As

Vhl RNAi

Key Links

Genomic Maps

JBrowse

Transgenic product class

RNAi_reagent

(Keleman et al., 2009.8.5)

Mutagen

in vitro construct

Nature of the Allele

Transgenic product class

RNAi_reagent

(Keleman et al., 2009.8.5)

Mutagen

in vitro construct

(Keleman et al., 2009.8.5)

Progenitor genotype

Carried in construct

P{KK111257}

Cytology

Description

UASt regulatory sequences drive expression of an inverted repeat.

(Keleman et al., 2009.8.5)

Allele components

Component

Use(s)

Regulatory region(s)

UASt

binary expression system - regulatory region

Encoded product / tool

dsRNA-KK111257

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 1 )

Disease

Interaction

References

ameliorates Parkinson's disease 1

modeled by Hsap\SNCA^UAS.cJa

(Ren et al., 2022)

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

abnormal body color | adult stage, with Scer\GAL4^pnr-MD237

(Zhang et al., 2021)

Phenotype Manifest In

adult external abdomen, with Scer\GAL4^pnr-MD237

(Zhang et al., 2021)

adult external thorax, with Scer\GAL4^pnr-MD237

(Zhang et al., 2021)

Detailed Description

Statement

Reference

The expression of Vhl^KK111257 under the control of Scer\GAL4^pnr-MD237 induces hyperpigmentation along the dorsal midline in the adult thorax; at higher expression levels, there is increased hyperpigmentation in the abdomen and hypopigmentation in the abdomen.

(Zhang et al., 2021)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Enhanced by

Statement

Reference

Scer\GAL4^pnr-MD237, Vhl^KK111257 has abnormal body color | adult stage phenotype, enhanceable by Ctr1A^{dN.UAS.Tag:FLAG}, Scer\GAL4^pnr-MD237

(Zhang et al., 2021)

Scer\GAL4^pnr-MD237, Vhl^KK111257 has abnormal body color | adult stage phenotype, enhanceable by Ctr1A^GD16726, Scer\GAL4^pnr-MD237

(Zhang et al., 2021)

Suppressed by

Statement

Reference

Scer\GAL4^pnr-MD237, Vhl^KK111257 has abnormal body color | adult stage phenotype, suppressible by Hsap\VHL^UAS.Tag:HA, Scer\GAL4^pnr-MD237

(Zhang et al., 2021)

Scer\GAL4^pnr-MD237, Vhl^KK111257 has abnormal body color | adult stage phenotype, suppressible by Scer\GAL4^pnr-MD237/sima^HMS00832

(Zhang et al., 2021)

Scer\GAL4^pnr-MD237, Vhl^KK111257 has abnormal body color | adult stage phenotype, suppressible by Scer\GAL4^pnr-MD237/ple^HMC06137

(Zhang et al., 2021)

Scer\GAL4^pnr-MD237, Vhl^KK111257 has abnormal body color | adult stage phenotype, suppressible by Ddc^JF02356, Scer\GAL4^pnr-MD237

(Zhang et al., 2021)

Scer\GAL4^pnr-MD237, Vhl^KK111257 has abnormal body color | adult stage phenotype, suppressible | partially by Scer\GAL4^pnr-MD237/cnc^KK101639

(Zhang et al., 2021)

Scer\GAL4^pnr-MD237, Vhl^KK111257 has abnormal body color | adult stage phenotype, suppressible by Ctr1A^GD16726, Scer\GAL4^pnr-MD237

(Zhang et al., 2021)

NOT suppressed by

Statement

Reference

Scer\GAL4^pnr-MD237, Vhl^KK111257 has abnormal body color | adult stage phenotype, non-suppressible by Ddc^UAS.cTa, Scer\GAL4^pnr-MD237

(Zhang et al., 2021)

Other

Statement

Reference

Ddc^JF02356, Scer\GAL4^pnr-MD237, Vhl^KK111257 has lethal phenotype

(Zhang et al., 2021)

Phenotype Manifest In

Enhanced by

Statement

Reference

Scer\GAL4^pnr-MD237, Vhl^KK111257 has adult external thorax phenotype, enhanceable by Ctr1A^{dN.UAS.Tag:FLAG}, Scer\GAL4^pnr-MD237

(Zhang et al., 2021)

Scer\GAL4^pnr-MD237, Vhl^KK111257 has adult external abdomen phenotype, enhanceable by Ctr1A^GD16726, Scer\GAL4^pnr-MD237

(Zhang et al., 2021)

Suppressed by

Statement

Reference

Scer\GAL4^pnr-MD237, Vhl^KK111257 has adult external thorax phenotype, suppressible by Scer\GAL4^pnr-MD237/ple^HMC06137

(Zhang et al., 2021)

Scer\GAL4^pnr-MD237, Vhl^KK111257 has adult external thorax phenotype, suppressible by Ddc^JF02356, Scer\GAL4^pnr-MD237

(Zhang et al., 2021)

Scer\GAL4^pnr-MD237, Vhl^KK111257 has adult external thorax phenotype, suppressible | partially by Scer\GAL4^pnr-MD237/cnc^KK101639

(Zhang et al., 2021)

Scer\GAL4^pnr-MD237, Vhl^KK111257 has adult external abdomen phenotype, suppressible | partially by Scer\GAL4^pnr-MD237/cnc^KK101639

(Zhang et al., 2021)

Scer\GAL4^pnr-MD237, Vhl^KK111257 has adult external thorax phenotype, suppressible by Ctr1A^GD16726, Scer\GAL4^pnr-MD237

(Zhang et al., 2021)

Scer\GAL4^pnr-MD237, Vhl^KK111257 has adult external thorax phenotype, suppressible by Hsap\VHL^UAS.Tag:HA, Scer\GAL4^pnr-MD237

(Zhang et al., 2021)

Scer\GAL4^pnr-MD237, Vhl^KK111257 has adult external thorax phenotype, suppressible by Scer\GAL4^pnr-MD237/sima^HMS00832

(Zhang et al., 2021)

NOT suppressed by

Statement

Reference

Scer\GAL4^pnr-MD237, Vhl^KK111257 has adult external thorax phenotype, non-suppressible by Ddc^UAS.cTa, Scer\GAL4^pnr-MD237

(Zhang et al., 2021)

Additional Comments

Genetic Interactions

Statement

Reference

The co-expression of Vhl^KK111257 and Ddc^JF02356 under the control of Scer\GAL4^pnr-MD237 at high levels leads to lethality. At lower levels, it suppresses the thoracic hyperpigmentation generated by the expression of Vhl^KK111257 alone.

(Zhang et al., 2021)

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Comments

Images (0)

Mutant

Wild-type

Stocks (1)

VDRC

v108920

P{KK111257}VIE-260B

Notes on Origin

Discoverer

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (1)

Reported As

Symbol Synonym

Vhl^KK111257

(Ren et al., 2022)

Name Synonyms

Secondary FlyBase IDs

References (5)

Report Sections

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