FB2026_02 , released June 18, 2026
Allele: Dmel\bunA-149B
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General Information
Symbol
Dmel\bunA-149B
Species
D. melanogaster
Name
FlyBase ID
FBal0221068
Feature type
allele
Associated gene
Dmel\bun
Associated Insertion(s)
Carried in Construct
Key Links
Genomic Maps

Allele class
Mutagen
Nature of the Allele
Allele class
Mutagen
Delta2-3 transposase
(Gluderer et al., 2008)
Progenitor genotype
bunGE12327
(Gluderer et al., 2008)
Cytology
Description

Imprecise excision of the insertion in bunGE12327, resulting in a deletion that affects bun isoforms A and F; the deletion starts 343bp upstream of the bun A start codon and extends for 2513bp.

(Gluderer et al., 2008)
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
deletion
2L:12,537,485..12,539,997 [-]
Comment:

Deletion resulting from the imprecise excision of P{EP}bunGE12327. The deletion starts 343bp upstream of the bun A start codon and extends for 2513bp.

(Gluderer et al., 2008)
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      Homozygotes die mostly at the larval stage.

      Mosaic flies with eye and head capsules largely homozygous for bunA-149B (generated using the eyFLP/FRT technique) have small heads ("pinhead" phenotype). The number of ommatidia in these mosaics is significantly reduced compared to wild type and the mutant photoreceptors are smaller than the surrounding heterozygous cells.

      bunA-149B/Df(2L)Exel6033 larvae develop more slowly than normal and die during the second and third larval instars.

      Heterozygous and bunA-149B/bunGE12327 males and females show a reduction in body weight compared to controls.

      Heterozygous and bunA-149B/bunGE12327 females show a reduction in ommatidia number and size compared to controls.

      (Gluderer et al., 2008)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      Additional Comments
      Genetic Interactions
      Statement
      Reference
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Comments
      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (2)
      Reported As
      Symbol Synonym
      A-149B
      (Gluderer et al., 2008)
      bunA-149B
      Name Synonyms
      Secondary FlyBase IDs
        References (1)