FlyBase Allele Report: Dmel\yata[KE2.1]

General Information

Symbol

Dmel\yata^KE2.1

Species

D. melanogaster

Name

FlyBase ID

FBal0221082

Feature type

allele

Associated gene

Dmel\yata

Associated Insertion(s)

P{3'hs-hig.HA}yata^KE2.1

Carried in Construct

Key Links

Genomic Maps

JBrowse

Allele class

Mutagen

Delta2-3 transposase

Nature of the Allele

Allele class

Mutagen

Delta2-3 transposase

(Sone et al., 2009)

Progenitor genotype

yata^25A

(Sone et al., 2009)

Associated Insertion(s)

P{3'hs-hig.HA}yata^KE2.1

Cytology

Description

Imprecise excision of the P{hs-hig.HA} insertion in yata^25A, resulting in a 6148bp deletion of genomic sequence that removes almost the entire yata gene. A 10bp sequence of the 3' end of P-element insertion is present.

(Sone et al., 2009)

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

delins

3R:29,749,278..29,755,426 [+]

Comment:

Deletion of 6148 bp resulting from the excision of P{hs-hig.HA}yata^25A. 10 bp from the 3' end of the P element remain.

(Sone et al., 2009)

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 1 )

Disease

Evidence

References

model of autosomal recessive spinocerebellar ataxia 21

CEA

(Sone et al., 2009)

Modifiers Based on Experimental Evidence ( 1 )

Disease

Interaction

References

model of autosomal recessive spinocerebellar ataxia 21

is ameliorated by hig^UAS.Tag:HA

(Sone et al., 2009)

is ameliorated by Appl^UAS.Tag:HA

(Sone et al., 2009)

ameliorates Alzheimer's disease 1

modeled by Hsap\APP^{695-Swedish.UAS.Tag:MYC}

(Furotani et al., 2018)

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

abnormal neuroanatomy | adult stage

(Sone et al., 2009)

abnormal planar polarity | adult stage

(Sone et al., 2009)

short lived

(Arimoto et al., 2020, Sone et al., 2009)

Phenotype Manifest In

interommatidial bristle

(Sone et al., 2009)

lens

(Sone et al., 2009)

ommatidium

(Sone et al., 2009)

rhabdomere

(Sone et al., 2009)

supraesophageal ganglion

(Sone et al., 2009)

wing

(Sone et al., 2009)

Detailed Description

Statement

Reference

Homozygous flies start to die after eclosion and show a shorter lifespan than controls.

Homozygotes show various eye defects, including an irregular arrangement of ommatidia, black coloured ommatidia and lens and bristle defects. Examination of the internal morphology of the eye reveals tissue polarity defects, abnormal rhabdomere numbers and vacuolisation at day 0 after eclosion. There is a large increase in vacuolisation in 7 day old flies raised in 12 hour light/12 hour dark conditions (vacuolisation is suppressed in constant dark conditions).

Homozygous flies show central brain volumes that are indistinguishable from wild type at day 0 after eclosion, but at day 14 after eclosion, the central brain volume of the mutant flies is significantly reduced compared to that of controls.

10% of mutant flies show a notched wing phenotype.

(Sone et al., 2009)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Enhanced by

Statement

Reference

yata^KE2.1 has short lived phenotype, enhanceable by Appl^d/Df(1)vnd^D38

(Sone et al., 2009)

NOT Enhanced by

Statement

Reference

yata^KE2.1 has short lived phenotype, non-enhanceable by w¹¹¹⁸

(Arimoto et al., 2020)

Suppressed by

Statement

Reference

yata^KE2.1 has short lived phenotype, suppressible | partially by Appl^UAS.Tag:HA/Scer\GAL4^elav.PLu

(Sone et al., 2009)

yata^KE2.1 has short lived phenotype, suppressible | partially by hig^UAS.Tag:HA/Scer\GAL4^elav.PLu

(Sone et al., 2009)

NOT suppressed by

Statement

Reference

yata^KE2.1 has short lived phenotype, non-suppressible by w¹¹¹⁸

(Arimoto et al., 2020)

Phenotype Manifest In

Suppressed by

Statement

Reference

yata^KE2.1 has supraesophageal ganglion phenotype, suppressible by Appl^UAS.Tag:HA/Scer\GAL4^elav.PLu

(Sone et al., 2009)

Enhancer of

Statement

Reference

yata^KE2.1 is an enhancer of ommatidium phenotype of w¹¹¹⁸

(Arimoto et al., 2020)

yata^KE2.1 is an enhancer of autophagosome | increased number phenotype of w¹¹¹⁸

(Arimoto et al., 2020)

yata^KE2.1 is an enhancer of late endosome | increased number phenotype of w¹¹¹⁸

(Arimoto et al., 2020)

Other

Statement

Reference

Appl^d/Df(1)vnd^D38, yata^KE2.1 has supraesophageal ganglion phenotype

(Sone et al., 2009)

Additional Comments

Genetic Interactions

Statement

Reference

Expression of Appl^{Scer\UAS.T:Ivir\HA1} or hig^{Scer\UAS.T:Ivir\HA1} under the control of Scer\GAL4^elav.PLu partially rescues the shortened lifespan of yata^KE2.1 homozygotes.

Expression of Appl^{Scer\UAS.T:Ivir\HA1} under the control of Scer\GAL4^elav.PLu rescues the reduced central brain volume seen in 14 day old yata^KE2.1 homozygous adults.

yata^KE2.1/yata^KE2.1 Appl^d/Df(1)vnd^D38 double mutant adults show a significant reduction in central brain volume at 0 days after eclosion.

The reduction in lifespan seen in yata^KE2.1 homozygous adults is more severe if the flies are also carrying Appl^d/Df(1)vnd^D38.

(Sone et al., 2009)

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Partially rescued by

yata^KE2.1 is partially rescued by yata^UAS.Tag:HA/Scer\GAL4^elav.PLu

(Sone et al., 2009)

Comments

Images (0)

Mutant

Wild-type

Stocks (0)

Notes on Origin

Discoverer

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (1)

Reported As

Symbol Synonym

yata^KE2.1

(Saito et al., 2021, Furotani et al., 2018, Sone et al., 2009)

Name Synonyms

Secondary FlyBase IDs

References (4)

Report Sections

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