FB2026_02 , released June 18, 2026
Allele: Dmel\Sxlf24,M1
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General Information
Symbol
Dmel\Sxlf24,M1
Species
D. melanogaster
Name
FlyBase ID
FBal0221177
Feature type
allele
Associated gene
Dmel\Sxl
Associated Insertion(s)
Carried in Construct
Key Links
Allele class

hypomorphic allele - genetic evidence

Mutagen
Nature of the Allele
Allele class

hypomorphic allele - genetic evidence

(Sun and Cline, 2009)
Mutagen
gamma ray
(Sun and Cline, 2009)
Progenitor genotype
SxlM1
(Sun and Cline, 2009)
Cytology
Description

CC to At change at position 12,771, which substitutes Asn for a conserved Thr residue just upstream of RNP2 in the second RNA recognition motif.

(Sun and Cline, 2009)
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      Sxlf24,M1/Sxlf4 females show high levels of X chromosome nondisjunction. Recombination across the y-sn interval on the X chromosome is only 0.5% that of controls, recombination across the 2nd chromosome is only 5% that of controls and recombination across the 3rd chromosome is only 7% that of controls.

      (Sun and Cline, 2009)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      Additional Comments
      Genetic Interactions
      Statement
      Reference
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Comments

      Sxlf24,M1 complements Sxlf4 well for female fertility but poorly for meiosis defects.

      (Sun and Cline, 2009)
      Images (0)
      Mutant
      Wild-type
      Stocks (1)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (1)
      Reported As
      Symbol Synonym
      Sxlf24,M1
      (Sun and Cline, 2009)
      Name Synonyms
      Secondary FlyBase IDs
        References (1)