FB2026_01 , released March 12, 2026
FB2026_01 , released March 12, 2026
Allele: Dmel\mopT612
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General Information
Symbol
Dmel\mopT612
Species
D. melanogaster
Name
FlyBase ID
FBal0221263
Feature type
allele
Associated gene
Dmel\mop
Associated Insertion(s)
Carried in Construct
Key Links
Genomic Maps

Allele class
Mutagen
Nature of the Allele
Allele class
Mutagen
ethyl methanesulfonate
(Miura et al., 2008)
Progenitor genotype
Cytology
Description

Amino acid replacement: Q351term.

(Miura et al., 2008)
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
point_mutation
3L:14,774,475..14,774,475 [-]
Nucleotide change:

C14774475T

Amino acid change:

Q351term | mop-PA

Reported amino acid change:

Q351term

Comment:

Site of nucleotide substitution in mutant inferred by FlyBase based on reported amino acid change.

(Miura et al., 2008)
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      Fewer photoreceptor cells than normal are present in homozygous clones in the eye disc, although R8 differentiation appears almost normal. Homozygous clones posterior to the morphogenetic furrow show increased cell death and an increased number of cells re-entering the cell cycle compared to wild-type cells.

      Homozygous clones in the adult wing show loss of wing vein material.

      (Miura et al., 2008)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      Suppressed by
      Statement
      Reference

      mopT612 has eye photoreceptor cell | somatic clone phenotype, suppressible by CblF165

      (Miura et al., 2008)

      mopT612 has eye photoreceptor cell | somatic clone phenotype, suppressible by styΔ5

      (Miura et al., 2008)
      NOT suppressed by
      Additional Comments
      Genetic Interactions
      Statement
      Reference

      The loss of photoreceptor cells seen in homozygous mopT612 clones in the eye disc is not rescued by expression of btl::EgfrScer\UAS.T:λ\cI-DD under the control of Scer\GAL4unspecified.

      Excessive photoreceptor differentiation can occur in mopT612 clones in the eye disc which are also expressing Ras85DV12.Scer\UAS under the control of Scer\GAL4unspecified.

      The loss of photoreceptor cells seen in homozygous mopT612 clones in the eye disc is not rescued if the clones are also homozygous for argosΔ7, but is rescued if the clones are also homozygous for either CblF165 or styΔ5.

      (Miura et al., 2008)
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Comments
      Images (0)
      Mutant
      Wild-type
      Stocks (1)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (2)
      Reported As
      Symbol Synonym
      mopT612
      (Lin et al., 2021, Courgeon et al., 2018, Chen et al., 2012, Miura et al., 2008)
      Name Synonyms
      myopicT612
      (Lee et al., 2009)
      Secondary FlyBase IDs
        References (5)