FB2026_03 , released September 17, 2026
Allele: Dmel\Or83cMB11142
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General Information
Symbol
Dmel\Or83cMB11142
Species
D. melanogaster
Name
FlyBase ID
FBal0221434
Feature type
allele
Associated gene
Dmel\Or83c
Associated Insertion(s)
Mi{ET1}Or83cMB11142
Carried in Construct
Key Links
Genomic Maps

Allele class
Mutagen
    Nature of the Allele
    Allele class
    Mutagen
    Progenitor genotype
    Associated Insertion(s)
    Mi{ET1}Or83cMB11142
    Cytology
    Description

    Insertion of Mi{ET1}Or83cMB11142 into the first exon of Or83c is confirmed by sequencing of genomic DNA prepared from mutant animals.

    (Ronderos et al., 2014)
    Allele components
    Component
    Use(s)
    Inserted element
    Mi{ET1}
    Encoded product / tool
    GAL4
    Mutations Mapped to the Genome
    Curation Data
    Variant Molecular Consequences
    Associated Sequence Data
    DDBJ / EMBL / GenBank
    DNA sequence
    Protein sequence
     
    UniProtKB/Swiss-Prot
      UniProtKB/TrEMBL
        Expression Data
        Reporter Expression
        Additional Information
        Statement
        Reference
         
        Marker for
        Reflects expression of
        Reporter construct used in assay
        Human Disease Associations
        Disease Ontology (DO) Annotations
        Models Based on Experimental Evidence ( 0 )
        Disease
        Evidence
        References
        Modifiers Based on Experimental Evidence ( 0 )
        Disease
        Interaction
        References
        Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
         
        Disease-implicated variant(s)
         
        Phenotypic Data
        Phenotypic Class
        Phenotype Manifest In
        Detailed Description
        Statement
        Reference

        Or83cMB11142 abolishes the response of ai2 sensilla/Or83c neuron to farnesol and 3-hexanol.

        (Scheuermann and Smith, 2019)

        In contrast to wild-type, antennal intermediate 2 (ai2) neurons from Or83cMB11142 mutants are completely insensitive to farnesol.

        Driving Or83cScer\UAS.cRa with Scer\GAL4Or23a.PC in Or83cMB11142 mutant background confers farnesol sensitivity to ai2b neurons.

        The electrophysiological response to grapefruit rind seen in wild-type neurons is abolished in Or83cMB11142 mutants.

        Wild-type flies are robustly attracted by farnesol even at dilutions of 1:10 [5]. Farnesol attraction in Or83cMB11142 mutant flies is significantly impaired at all concentrations tested and completely abolished at 10[5] or greater dilutions.

        Attraction behaviour of Or83cMB11142 mutant flies remains intact toward apple cider vinegar. This is the same behaviour as the one observed in wild-type.

        (Ronderos et al., 2014)
        External Data
        Interactions
        Show genetic interaction network for Enhancers & Suppressors
        Phenotypic Class
        Phenotype Manifest In
        Additional Comments
        Genetic Interactions
        Statement
        Reference
        Xenogenetic Interactions
        Statement
        Reference
        Complementation and Rescue Data
        Images (0)
        Mutant
        Wild-type
        Stocks (1)
        Notes on Origin
        Discoverer
        External Crossreferences and Linkouts ( 0 )
        Synonyms and Secondary IDs (1)
        Reported As
        Symbol Synonym
        Or83cMB11142
        (Scheuermann and Smith, 2019, Ronderos et al., 2014, Bellen, 2009.5.28)
        Name Synonyms
        Secondary FlyBase IDs
          References (3)