FlyBase Allele Report: Dmel\Manf[Δ112]

General Information

Symbol

Dmel\Manf^Δ112

Species

D. melanogaster

Name

FlyBase ID

FBal0221494

Feature type

allele

Associated gene

Dmel\Manf

Associated Insertion(s)

Carried in Construct

Key Links

Genomic Maps

JBrowse

Allele class

Mutagen

Nature of the Allele

Allele class

Mutagen

Progenitor genotype

P{SUPor-P}CG14879^KG03250

(Palgi et al., 2009)

Cytology

Description

Imprecise excision of the P{SUPor-P}CG14879^KG03250 insertion, resulting in a deletion that removes 15bp of the Manf 5'UTR.

(Palgi et al., 2009)

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

deletion

3R:16,349,255..16,349,427 [+]

Comment:

Aprroximate endpoints of deletion resulting from the imprecise excision of P{SUPor-P}CG14879^KG03250, described as removing the first 15 nucleotides of the Manf transcript. The transcription start from R5.12 was used for the mapping.

(Palgi et al., 2009)

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

abnormal locomotor behavior | larval stage | recessive

(Palgi et al., 2009)

abnormal stress response

(Neves et al., 2016)

lethal - all die before end of first instar larval stage | recessive

(Neves et al., 2016)

lethal - all die before end of larval stage | recessive

(Palgi et al., 2009)

some die during larval stage | recessive

(Palgi et al., 2009)

visible | adult stage

(Neves et al., 2016)

Phenotype Manifest In

eye | adult stage

(Neves et al., 2016)

Detailed Description

Statement

Reference

Manf^Δ112/+ heterozygous adult flies show decreased eye tissue regeneration capacity upon UV radiation induced damage (inflicted during pupal stage) compared to wild-type.

(Neves et al., 2016)

Homozygotes die as later first instar larvae or immediately after the delayed first moult with defects in behaviour; the larvae atypically wander away from the food, then move more slowly and finally freeze, immobilised but still responding to touch.

(Palgi et al., 2009)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Phenotype Manifest In

Additional Comments

Genetic Interactions

Statement

Reference

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Rescued by

Manf[+]/Manf^Δ112 is rescued by Scer\GAL4^Hml.Δ/Manf^UAS.cPa

(Neves et al., 2016)

Comments

The increased severity of eye degeneration after exposure of one eye to UV irradiation during pupal stage characteristic for Manf^Δ112/+ adults can be rescued by expression of Manf^Scer\UAS.cPa under the control of Scer\GAL4^Hml.Δ.

(Neves et al., 2016)

Images (0)

Mutant

Wild-type

Stocks (0)

Notes on Origin

Discoverer

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (3)

Reported As

Symbol Synonym

DmMANF^Δ112

(Palgi et al., 2009)

Manf^Δ112

manf^mut112

(Neves et al., 2016)

Name Synonyms

Secondary FlyBase IDs

References (2)

Report Sections

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