FlyBase Allele Report: Dmel\Taf3[UAS.cPa]

General Information

Symbol

Dmel\Taf3^UAS.cPa

Species

D. melanogaster

Name

FlyBase ID

FBal0221664

Feature type

allele

Associated gene

Dmel\Taf3

Associated Insertion(s)

Carried in Construct

P{UAS-Taf3.P}

Also Known As

UAS-Bip2

Key Links

Transgenic product class

wild_type

(Prince, 2009.6.21)

Mutagen

in vitro construct

Nature of the Allele

Transgenic product class

wild_type

(Prince, 2009.6.21)

Mutagen

in vitro construct

(Prince, 2009.6.21)

Progenitor genotype

Carried in construct

P{UAS-Taf3.P}

Cytology

Description

UAS regulatory sequences drive expression of bip2 coding sequences.

(Prince, 2009.6.21)

Allele components

Component

Use(s)

Regulatory region(s)

UAS

binary expression system - regulatory region

Encoded product / tool

Taf3

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

Phenotype Manifest In

Detailed Description

Statement

Reference

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Phenotype Manifest In

Enhancer of

Statement

Reference

Taf3^UAS.cPa/Scer\GAL4^ey.PH is an enhancer of eye phenotype of Antp^UAS.cBa, Scer\GAL4^ey-OK107

(Prince et al., 2008)

Taf3^UAS.cPa/Scer\GAL4^ey.PH is an enhancer of wing | ectopic phenotype of Antp^UAS.cBa, Scer\GAL4^ey-OK107

(Prince et al., 2008)

Taf3^UAS.cPa, Scer\GAL4^ey.PH is an enhancer of wing | ectopic phenotype of Antp^UAS.cBa, N^act.sev, Scer\GAL4^ey.PH

(Prince et al., 2008)

Taf3^UAS.cPa, Scer\GAL4^ey.PH is an enhancer of eye phenotype of Antp^UAS.cBa, N^act.sev, Scer\GAL4^ey.PH

(Prince et al., 2008)

Additional Comments

Genetic Interactions

Statement

Reference

The penetrance of the eye-to-wing transformation found in Scer\GAL4^ey.PH; Antp^Scer\UAS.cBa mutants is increased upon ectopic co-expression of bip2^Scer\UAS.cPa from 8% to 24%.

Ectopic expression of bip2^Scer\UAS.cPa in combination with Antp^Scer\UAS.cBa and N^act.sev, under the control of Scer\GAL4^ey.PH strongly enhances the penetrance of eye-to-wing transformation. About 80% of these flies show eye-to-wing transformation compared with 40% without co-expression of bip2^Scer\UAS.cPa.

Ectopic expression of bip2^Scer\UAS.cPa in combination with Antp^Scer\UAS.cBa and N^act.sev, under the control of Scer\GAL4^ey.PH reduces the fraction of flies that show antenna-to-leg transformation from 28% to 13%.

Ectopic expression of bip2^Scer\UAS.cPa in combination with Antp^{AAAA.Scer\UAS} and N^act.sev, under the control of Scer\GAL4^ey.PH appears to not affect eye-to-wing nor antenna-to-leg transformation, indicating a requirement of the YPWM motif for the Antp/bip2 interaction.

(Prince et al., 2008)

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Comments

Images (0)

Mutant

Wild-type

Stocks (2)

Bloomington

26878

y¹ w^*; P{UAS-Taf3.P}2

26880

y¹ w^*; P{UAS-Taf3.P}3

Notes on Origin

Discoverer

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (3)

Reported As

Symbol Synonym

Taf3^UAS.cPa

bip2^Scer\UAS.cPa

bip2^UAS.cPa

Name Synonyms

Secondary FlyBase IDs

References (3)

Report Sections

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