FlyBase Allele Report: Dmel\14-3-3ε[NP1301]

General Information

Symbol

Dmel\14-3-3ε^NP1301

Species

D. melanogaster

Name

FlyBase ID

FBal0223209

Feature type

allele

Associated gene

Dmel\14-3-3ε

Associated Insertion(s)

P{GawB}14-3-3ε^NP1301

Carried in Construct

Key Links

Genomic Maps

JBrowse

Allele class

Mutagen

Nature of the Allele

Allele class

Mutagen

Progenitor genotype

Associated Insertion(s)

P{GawB}14-3-3ε^NP1301

Cytology

Description

Allele components

Component

Use(s)

Inserted element

P{GawB}

enhancer trap

Encoded product / tool

GAL4

binary expression system - driver

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

transposable_element_insertion_site

3R:18,243,685..18,243,685 [-]

(FlyBase Curators, 2008-)

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

abnormal neuroanatomy (with 14-3-3ε^j2B10)

(Yang and Terman, 2012)

Phenotype Manifest In

larval intersegmental nerve branch ISNb of A1-7 (with 14-3-3ε^j2B10)

(Yang and Terman, 2012)

larval segmental nerve branch SNa of A1-7 (with 14-3-3ε^j2B10)

(Yang and Terman, 2012)

Detailed Description

Statement

Reference

14-3-3ε^j2B10/14-3-3ε^NP1301 embryos show highly penetrant axon guidance defects in the ISNb and SNa axons.

(Yang and Terman, 2012)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Suppressed by

Statement

Reference

14-3-3ε^j2B10/14-3-3ε^NP1301 has abnormal neuroanatomy phenotype, suppressible by Scer\GAL4^NP1301/Ras64B^Val14.UAS

(Yang and Terman, 2012)

14-3-3ε^j2B10/14-3-3ε^NP1301 has abnormal neuroanatomy phenotype, suppressible by Scer\GAL4^NP1301/if^UAS.cUa

(Yang and Terman, 2012)

14-3-3ε^j2B10/14-3-3ε^NP1301 has abnormal neuroanatomy phenotype, suppressible by Scer\GAL4^NP1301/mew^UAS.cWa

(Yang and Terman, 2012)

Phenotype Manifest In

Suppressed by

Statement

Reference

14-3-3ε^j2B10/14-3-3ε^NP1301 has larval intersegmental nerve branch ISNb of A1-7 phenotype, suppressible by Scer\GAL4^NP1301/Ras64B^Val14.UAS

(Yang and Terman, 2012)

14-3-3ε^j2B10/14-3-3ε^NP1301 has larval segmental nerve branch SNa of A1-7 phenotype, suppressible by Scer\GAL4^NP1301/Ras64B^Val14.UAS

(Yang and Terman, 2012)

14-3-3ε^j2B10/14-3-3ε^NP1301 has larval intersegmental nerve branch ISNb of A1-7 phenotype, suppressible by Scer\GAL4^NP1301/if^UAS.cUa

(Yang and Terman, 2012)

14-3-3ε^j2B10/14-3-3ε^NP1301 has larval segmental nerve branch SNa of A1-7 phenotype, suppressible by Scer\GAL4^NP1301/if^UAS.cUa

(Yang and Terman, 2012)

14-3-3ε^j2B10/14-3-3ε^NP1301 has larval intersegmental nerve branch ISNb of A1-7 phenotype, suppressible by Scer\GAL4^NP1301/mew^UAS.cWa

(Yang and Terman, 2012)

14-3-3ε^j2B10/14-3-3ε^NP1301 has larval segmental nerve branch SNa of A1-7 phenotype, suppressible by Scer\GAL4^NP1301/mew^UAS.cWa

(Yang and Terman, 2012)

Additional Comments

Genetic Interactions

Statement

Reference

The ISNb and SNa axon guidance defects seen in 14-3-3ε^j2B10/14-3-3ε^NP1301 embryos are significantly suppressed by expression of either Ras64B^{Val14.Scer\UAS}, if^Scer\UAS.cUa or mew^Scer\UAS.cWa under the control of Scer\GAL4^{14-3-3ε-NP1301}.

(Yang and Terman, 2012)

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Partially rescued by

14-3-3ε^j2B10/14-3-3ε^NP1301 is partially rescued by Scer\GAL4^NP1301/14-3-3ε^UAS.Tag:FLAG

(Yang and Terman, 2012)

Comments

The ISNb and SNa axon guidance defects seen in 14-3-3ε^j2B10/14-3-3ε^NP1301 embryos are partially suppressed by expression of 14-3-3ε^{Scer\UAS.T:Zzzz\FLAG} under the control of Scer\GAL4^{14-3-3ε-NP1301}.

(Yang and Terman, 2012)

Images (0)

Mutant

Wild-type

Stocks (1)

Kyoto

103972

y^* w^*; P{GawB}14-3-3ε^NP1301 / TM6, P{UAS-lacZ.UW23-1}UW23-1

Notes on Origin

Discoverer

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (1)

Reported As

Symbol Synonym

14-3-3ε^NP1301

(Yang and Terman, 2012)

Name Synonyms

Secondary FlyBase IDs

References (2)

Report Sections

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