FB2026_01 , released March 12, 2026
FB2026_01 , released March 12, 2026
Allele: Dmel\fab131
Open Close
General Information
Symbol
Dmel\fab131
Species
D. melanogaster
Name
FlyBase ID
FBal0230155
Feature type
allele
Associated gene
Dmel\fab1
Associated Insertion(s)
Carried in Construct
Key Links
Genomic Maps

Allele class

loss of function allele

Mutagen
Nature of the Allele
Allele class

loss of function allele

(Rusten et al., 2006)
Mutagen
ethyl methanesulfonate
(Rusten et al., 2006)
Progenitor genotype
Cytology
Description

Amino acid replacement: L1321term.

(Rusten et al., 2006)
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
point_mutation
2R:17,776,955..17,776,955 [-]
Nucleotide change:

T17776955A

Amino acid change:

L1321term | fab1-PA; L1321term | fab1-PB

Reported amino acid change:

L1321term

Comment:

Site of nucleotide substitution in mutant inferred by FlyBase based on reported amino acid change.

(Rusten et al., 2006)
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      fab131/Df(2R)14H10W-30 pupae are larger than controls, even though these animals do not have an extended larval phase. Legs dissected from the mutant pharate adults are the correct length but are considerably thicker than normal.

      The Garland cells of fab131/Df(2R)14H10W-30 wandering third instar larvae are up to 3 times the normal diameter and their endosomes are dramatically enlarged compared to wild type. The imaginal discs of mutant larvae have larger cells than normal and show a disorganised distribution of nuclei relative to wild-type discs, although overall cell polarity is intact.

      (Rusten et al., 2006)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      Additional Comments
      Genetic Interactions
      Statement
      Reference
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Comments
      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (2)
      Reported As
      Symbol Synonym
      fab131
      (Rusten et al., 2007, Rusten et al., 2006)
      l(2)SJB31
      (Rusten et al., 2006)
      Name Synonyms
      Secondary FlyBase IDs
        References (2)