FB2026_01 , released March 12, 2026
FB2026_01 , released March 12, 2026
Allele: Dmel\aPKCRNAi.cRa.UAS
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General Information
Symbol
Dmel\aPKCRNAi.cRa.UAS
Species
D. melanogaster
Name
FlyBase ID
FBal0230309
Feature type
allele
Associated gene
Dmel\aPKC
Associated Insertion(s)
Carried in Construct
P{UAS-aPKC.RNAi.R}
Key Links
Transgenic product class
RNAi_reagent
(Ramachandran et al., 2009)
Mutagen
Nature of the Allele
Transgenic product class
RNAi_reagent
(Ramachandran et al., 2009)
Mutagen
in vitro construct
(Ramachandran et al., 2009)
Progenitor genotype
Carried in construct
P{UAS-aPKC.RNAi.R}
Cytology
Description

UASt regulatory sequences drive expression of a baz RNAi construct, which is directed against exons 6 and 7 of aPKC.

(Ramachandran et al., 2009)
Allele components
Component
Use(s)
Regulatory region(s)
UASt
Encoded product / tool
aPKC
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      Expression of aPKCdsRNA.cRa.Scer\UAS under the control of Scer\GAL4C57 results in a reduction of postsynaptic F-actin at the larval neuromuscular junction.

      Larvae expressing aPKCdsRNA.cRa.Scer\UAS under the control of Scer\GAL4C57 in the muscles show an increase in evoked excitatory junctional potential (EJP) amplitude compared to controls. The amplitude of miniature EJPs is increased in these animals compared to wild type, although the frequency of miniature EJPs is unaffected.

      (Ramachandran et al., 2009)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      Additional Comments
      Genetic Interactions
      Statement
      Reference
      Xenogenetic Interactions
      Statement
      Reference

      Co-expression of both aPKCdsRNA.cRa.Scer\UAS and BacA\p35Scer\UAS.cUa under the control of Scer\GAL4ap.PU results in tissue overgrowth and loss of apicobasal polarity in the wing disc.

      (Padash Barmchi et al., 2016)
      Complementation and Rescue Data
      Comments
      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (3)
      Reported As
      Symbol Synonym
      aPKCRNAi.cRa.UAS
      aPKCdsRNA.cRa.Scer\UAS
      aPKCdsRNA.cRa.UAS
      Name Synonyms
      Secondary FlyBase IDs
        References (3)