Imprecise excision of the progenitor insertion has resulted in an 1079 bp deletion removing all alternatively used transcription start sites of Tsp.
A 1079 bp deletion resulting from the imprecise excision of P{SUPor-P}KG08861.
TspΔ79/Tp(2;2)CA30 mutant embryos display muscle detachment defects. Muscle detachment starts after the first muscle contractions. Detachment results in the rounding up of the muscles which, however, remain loosely connected to neighboring muscles on one side of the segment, a phenomenon that results in gaps in the stereotypical muscle pattern. The extent and the patterns of muscle detachment varies from embryo to embryo and between individual segments. However, all embryos have in common that detachment is only seen in muscles that are spanned between tendon cells at the segment border, or in muscles that are linked to the tendon cells via indirect attachment complexes (this includes the lateral longitudinal as well as the ventral longitudinal muscle). The dorsal oblique and acute muscles are only partially disorganized but not detached and the lateral transverse and ventral acute muscles appear normal in most segments.
TspΔ79 has muscle attachment site phenotype, enhanceable by mewM6
TspΔ79 has muscle attachment site phenotype, enhanceable by ifB2
TspΔ79 is an enhancer of muscle attachment site phenotype of ifB2
Hemizygous mewM6/Y mutant embryos that are also homozygous for TspΔ79 display only a mild enhancement of the TspΔ79 single mutant muscle detachment phenotype.
ifB2/Y; TspΔ79 double mutant embryos develop dramatic muscle pattern defects which is beyond an additive effect of the two individual mutant phenotypes.
TspΔ79 is rescued by TspUAS.cCa/Scer\GAL4sr.239
