FB2026_02 , released June 18, 2026
Allele: Dmel\Vps28B9
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General Information
Symbol
Dmel\Vps28B9
Species
D. melanogaster
Name
FlyBase ID
FBal0230471
Feature type
allele
Associated gene
Dmel\Vps28
Associated Insertion(s)
Carried in Construct
Key Links
Genomic Maps

Allele class
Mutagen
Nature of the Allele
Allele class
Mutagen
ethyl methanesulfonate
(Vaccari et al., 2009)
Progenitor genotype
Cytology
Description

Vps28B9 contains a 16bp deletion.

(Vaccari et al., 2009)
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
deletion
2R:8,079,786..8,079,801 [-]
Comment:

16 bp deletion.

(Vaccari et al., 2009)
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      Vps28B9/Vps28B9 MARCM ddaC mutant clones show dendrite pruning defects at 18hr APF, compared to controls.

      (Loncle et al., 2015)

      Homozygous Vps28B9 mutant tissue partially survives in mosaic eye discs, and is not completely 'out-competed'. Although mutant ommatidia are not recovered, the wild-type ommatidia composing the adult eyes of mosaic animals are variably overgrown.

      Vps28B9 mutants exhibit neoplastic tumours.

      Compared with wild-type, egg chambers containing Vps28B9 mutant cells exhibit a loss of plasma membrane, ultimately leading to the formation of clusters of multinucleated cells enclosed by a single actin cytoskeleton, with nuclei rested around clumps of actin-positive structures, possibly also membrane fragments.

      (Vaccari et al., 2009)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      Suppressor of
      Statement
      Reference

      Vps28B9 is a suppressor of wing vein L5 phenotype of Df(3L)ru-22/rhove-1

      (Tjota et al., 2011)

      Vps28B9 is a suppressor of wing vein L5 phenotype of rhove-1

      (Tjota et al., 2011)
      Additional Comments
      Genetic Interactions
      Statement
      Reference

      A Vps28B9 heterozygous background leads to approximately 90% suppression of the L5 wing vein defect in both rhove-1/Df(3L)ru-22 kst1 and rhove-1/rhove-1 kst1 flies.

      (Tjota et al., 2011)
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Rescued by

      Vps28B9 is rescued by Scer\GAL4elav.PU/Vps28UAS.cSa

      (Zhang et al., 2014)
      Comments
      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (2)
      Reported As
      Symbol Synonym
      Vps28B9
      (Loncle et al., 2015, Zhang et al., 2014)
      vps28B9
      (Jiang et al., 2018, Tjota et al., 2011, Vaccari et al., 2009)
      Name Synonyms
      Secondary FlyBase IDs
        References (5)