FlyBase Allele Report: Dmel\fray[KK100424]

General Information

Symbol

Dmel\fray^KK100424

Species

D. melanogaster

Name

FlyBase ID

FBal0230739

Feature type

allele

Associated gene

Dmel\fray

Associated Insertion(s)

Carried in Construct

P{KK100424}

Key Links

Genomic Maps

JBrowse

Transgenic product class

RNAi_reagent

(Keleman et al., 2009.8.5)

Mutagen

in vitro construct

Nature of the Allele

Transgenic product class

RNAi_reagent

(Keleman et al., 2009.8.5)

Mutagen

in vitro construct

(Keleman et al., 2009.8.5)

Progenitor genotype

Carried in construct

P{KK100424}

Cytology

Description

UASt regulatory sequences drive expression of an inverted repeat.

(Keleman et al., 2009.8.5)

Allele components

Component

Use(s)

Regulatory region(s)

UASt

binary expression system - regulatory region

Encoded product / tool

dsRNA-KK100424

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

increased cell number | third instar larval stage, with Scer\GAL4^repo.PL

(Matzat et al., 2015)

Phenotype Manifest In

embryonic/larval wrapping glial cell | third instar larval stage, with Scer\GAL4^repo.PL

(Matzat et al., 2015)

nerve | third instar larval stage, with Scer\GAL4^repo.PL

(Matzat et al., 2015)

posterior wing margin, with Scer\GAL4^en.PU

(Serysheva et al., 2013)

Detailed Description

Statement

Reference

Expression of fray^KK100424 under the control of Scer\GAL4^repo.PL leads to prominent swellings in peripheral nerves and thus a local increase of the nerve surface, this is accompanied by a significant increase in the number of perineurial glial cells.

(Matzat et al., 2015)

Scer\GAL4^en.PU-mediated expression of fray^KK100424 (with Dcr-2^Scer\UAS.cDa) induces loss of posterior wing margin.

(Serysheva et al., 2013)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Phenotype Manifest In

NOT Enhancer of

Statement

Reference

Scer\GAL4^dpp.blk1/fray^KK100424 is a non-enhancer of wing margin bristle | ectopic phenotype of Scer\GAL4^dpp.blk1, fz2^{2-2-2.UAS.Tag:MYC}

(Serysheva et al., 2013)

NOT Suppressor of

Statement

Reference

Scer\GAL4^dpp.blk1/fray^KK100424 is a non-suppressor of wing margin bristle | ectopic phenotype of Scer\GAL4^dpp.blk1, fz2^{2-2-2.UAS.Tag:MYC}

(Serysheva et al., 2013)

Additional Comments

Genetic Interactions

Statement

Reference

Co-expression of fray^KK100424 has no effect on the ectopic margin bristles seen in Scer\GAL4^dpp.blk1 fz2^{2-2-2.Scer\UAS.T:Hsap\MYC} wings.

(Serysheva et al., 2013)

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Comments

Images (0)

Mutant

Wild-type

Stocks (1)

VDRC

v106919

P{KK100424}VIE-260B

Notes on Origin

Discoverer

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (2)

Reported As

Symbol Synonym

fray^KK100424

fray^dsRNA

(Matzat et al., 2015)

Name Synonyms

Secondary FlyBase IDs

References (7)

Report Sections

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