FlyBase Allele Report: Dmel\wnd[KK100521]

General Information

Symbol

Dmel\wnd^KK100521

Species

D. melanogaster

Name

FlyBase ID

FBal0230804

Feature type

allele

Associated gene

Dmel\wnd

Associated Insertion(s)

Carried in Construct

P{KK100521}

Also Known As

wnd RNAi, UAS-wnd-RNAi

Key Links

Genomic Maps

JBrowse

Transgenic product class

RNAi_reagent

(Keleman et al., 2009.8.5)

Mutagen

in vitro construct

Nature of the Allele

Transgenic product class

RNAi_reagent

(Keleman et al., 2009.8.5)

Mutagen

in vitro construct

(Keleman et al., 2009.8.5)

Progenitor genotype

Carried in construct

P{KK100521}

Cytology

Description

UASt regulatory sequences drive expression of an inverted repeat.

(Keleman et al., 2009.8.5)

Allele components

Component

Use(s)

Regulatory region(s)

UASt

binary expression system - regulatory region

Encoded product / tool

dsRNA-KK100521

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

Phenotype Manifest In

Detailed Description

Statement

Reference

Animals expressing wnd^KK100521 under the control of Scer\GAL4⁴⁷⁷ show severely reduced axon outgrowth in ddaC neurons after axon severing, while dendrite regeneration after complete removal of the dendrites appears normal.

ddaE neurons show robust dendrite regeneration after dendrite removal in animals expressing wnd^KK100521 under the control of Scer\GAL4²²¹.

(Stone et al., 2014)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Suppressor of

Statement

Reference

wnd^KK100521, Scer\GAL4^Toll-6-D42 is a suppressor | partially of abnormal neuroanatomy | larval stage phenotype of Pyk^GL00099, Scer\GAL4^Toll-6-D42

(Waller et al., 2025)

wnd^KK100521, Scer\GAL4^unspecified is a suppressor | partially of abnormal wound healing | larval stage phenotype of Pyk^GL00099, Scer\GAL4^unspecified

(Waller et al., 2025)

wnd^KK100521, Scer\GAL4^cv-c-C5 is a suppressor of abnormal size | adult stage phenotype of Dad1^GD1006, Scer\GAL4^cv-c-C5

(Zhang et al., 2016)

wnd^KK100521, Scer\GAL4^cv-c-C5 is a suppressor of visible | adult stage phenotype of Dad1^GD1006, Scer\GAL4^cv-c-C5

(Zhang et al., 2016)

wnd^KK100521, Scer\GAL4^en.PU is a suppressor of increased cell death | third instar larval stage phenotype of Dad1^GD1006, Scer\GAL4^en.PU

(Zhang et al., 2016)

Phenotype Manifest In

Suppressor of

Statement

Reference

wnd^KK100521, Scer\GAL4^Toll-6-D42 is a suppressor | partially of synapse | larval stage phenotype of Pyk^GL00099, Scer\GAL4^Toll-6-D42

(Waller et al., 2025)

wnd^KK100521, Scer\GAL4^Toll-6-D42 is a suppressor | partially of synaptic membrane | larval stage phenotype of Pyk^GL00099, Scer\GAL4^Toll-6-D42

(Waller et al., 2025)

wnd^KK100521, Scer\GAL4^unspecified is a suppressor | partially of axon | larval stage phenotype of Pyk^GL00099, Scer\GAL4^unspecified

(Waller et al., 2025)

wnd^KK100521, Scer\GAL4^cv-c-C5 is a suppressor of wing phenotype of Dad1^GD1006, Scer\GAL4^cv-c-C5

(Zhang et al., 2016)

wnd^KK100521, Scer\GAL4^en.PU is a suppressor of wing disc | third instar larval stage phenotype of Dad1^GD1006, Scer\GAL4^en.PU

(Zhang et al., 2016)

Additional Comments

Genetic Interactions

Statement

Reference

The small adult wing size along with the increased apoptosis in the third instar larval wing discs induced upon expression of Dad1^GD1006 driven by Scer\GAL4^C5 and Scer\GAL4^en.PU, respectively, is suppressed by co-expression of wnd^KK100521.

(Zhang et al., 2016)

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Comments

Images (0)

Mutant

Wild-type

Stocks (1)

VDRC

v103410

P{KK100521}VIE-260B

Notes on Origin

Discoverer

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (1)

Reported As

Symbol Synonym

wnd^KK100521

Name Synonyms

Secondary FlyBase IDs

References (12)

Report Sections

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