FlyBase Allele Report: Dmel\Tcs3[KK101323]

General Information

Symbol

Dmel\Tcs3^KK101323

Species

D. melanogaster

Name

FlyBase ID

FBal0231197

Feature type

allele

Associated gene

Dmel\Tcs3

Associated Insertion(s)

Carried in Construct

P{KK101323}

Key Links

Genomic Maps

JBrowse

Transgenic product class

RNAi_reagent

(Keleman et al., 2009.8.5)

Mutagen

in vitro construct

Nature of the Allele

Transgenic product class

RNAi_reagent

(Keleman et al., 2009.8.5)

Mutagen

in vitro construct

(Keleman et al., 2009.8.5)

Progenitor genotype

Carried in construct

P{KK101323}

Cytology

Description

UASt regulatory sequences drive expression of an inverted repeat.

(Keleman et al., 2009.8.5)

Allele components

Component

Use(s)

Regulatory region(s)

UASt

binary expression system - regulatory region

Encoded product / tool

dsRNA-KK101323

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 1 )

Disease

Evidence

References

model of Galloway-Mowat syndrome 3

CEC

(Krausel et al., 2023)

Modifiers Based on Experimental Evidence ( 1 )

Disease

Interaction

References

model of Galloway-Mowat syndrome 3

is ameliorated by Hsap\OSGEP^UAS.cKa

(Krausel et al., 2023)

is ameliorated by PEK^KK100348

(Krausel et al., 2023)

is exacerbated by crc^A.UAS.Tag:HA

(Krausel et al., 2023)

is ameliorated by crc^HMC06624

(Krausel et al., 2023)

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

Phenotype Manifest In

garland cell, with Scer\GAL4^sns.PU

(Krausel et al., 2023)

nephrocyte diaphragm, with Scer\GAL4^sns.PU

(Krausel et al., 2023)

wing, with Scer\GAL4^e22c

(Rojas-Benítez et al., 2017)

wing disc, with Scer\GAL4^hh-Gal4

(Rojas-Benítez et al., 2017)

Detailed Description

Statement

Reference

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Suppressed by

Statement

Reference

Scer\GAL4^sns.PU, Tcs3^KK101323 has decreased cell size phenotype, suppressible by Hsap\OSGEP^UAS.cKa, Scer\GAL4^sns.PU

(Krausel et al., 2023)

Scer\GAL4^sns.PU, Tcs3^KK101323 has increased cell death phenotype, suppressible by crc^HMC06624/Scer\GAL4^sns.PU

(Krausel et al., 2023)

Scer\GAL4^sns.PU, Tcs3^KK101323 has decreased cell size phenotype, suppressible by crc^HMC06624/Scer\GAL4^sns.PU

(Krausel et al., 2023)

Scer\GAL4^sns.PU, Tcs3^KK101323 has increased cell death phenotype, suppressible by PEK^KK100348, Scer\GAL4^sns.PU

(Krausel et al., 2023)

Scer\GAL4^e22c, Tcs3^KK101323 has decreased size | adult stage phenotype, suppressible | partially by Hsc70-3^UAS.cEa, Scer\GAL4^e22c

(Rojas-Benítez et al., 2017)

Scer\GAL4^e22c, Tcs3^KK101323 has visible | adult stage phenotype, suppressible | partially by Hsc70-3^UAS.cEa, Scer\GAL4^e22c

(Rojas-Benítez et al., 2017)

Scer\GAL4^e22c, Tcs3^KK101323 has decreased size | adult stage phenotype, suppressible | partially by Xbp1^UAS.HG.EGFP/Scer\GAL4^e22c

(Rojas-Benítez et al., 2017)

Scer\GAL4^e22c, Tcs3^KK101323 has visible | adult stage phenotype, suppressible | partially by Xbp1^UAS.HG.EGFP/Scer\GAL4^e22c

(Rojas-Benítez et al., 2017)

Scer\GAL4^e22c, Tcs3^KK101323 has decreased size | adult stage phenotype, suppressible by BacA\p35^UAS.cHa, Scer\GAL4^e22c

(Rojas-Benítez et al., 2017)

Scer\GAL4^e22c, Tcs3^KK101323 has visible | adult stage phenotype, suppressible by BacA\p35^UAS.cHa, Scer\GAL4^e22c

(Rojas-Benítez et al., 2017)

NOT suppressed by

Statement

Reference

Scer\GAL4^sns.PU, Tcs3^KK101323 has decreased cell size phenotype, non-suppressible by Hsap\OSGEP^C110R.UAS, Scer\GAL4^sns.PU

(Krausel et al., 2023)

Scer\GAL4^sns.PU, Tcs3^KK101323 has decreased cell size phenotype, non-suppressible by Hsap\OSGEP^I14F.UAS, Scer\GAL4^sns.PU

(Krausel et al., 2023)

Scer\GAL4^sns.PU, Tcs3^KK101323 has decreased cell size phenotype, non-suppressible by Hsap\OSGEP^R325Q.UAS, Scer\GAL4^sns.PU

(Krausel et al., 2023)

Scer\GAL4^sns.PU, Tcs3^KK101323 has decreased cell size phenotype, non-suppressible by Hsap\OSGEP^R247Q.UAS, Scer\GAL4^sns.PU

(Krausel et al., 2023)

Scer\GAL4^e22c, Tcs3^KK101323 has decreased size | adult stage phenotype, non-suppressible by bsk^DN.UAS/Scer\GAL4^e22c

(Rojas-Benítez et al., 2017)

Scer\GAL4^e22c, Tcs3^KK101323 has visible | adult stage phenotype, non-suppressible by bsk^DN.UAS/Scer\GAL4^e22c

(Rojas-Benítez et al., 2017)

Phenotype Manifest In

Suppressed by

Statement

Reference

Scer\GAL4^sns.PU, Tcs3^KK101323 has garland cell phenotype, suppressible by crc^HMC06624/Scer\GAL4^sns.PU

(Krausel et al., 2023)

Scer\GAL4^sns.PU, Tcs3^KK101323 has nephrocyte diaphragm phenotype, suppressible | partially by crc^HMC06624/Scer\GAL4^sns.PU

(Krausel et al., 2023)

Scer\GAL4^sns.PU, Tcs3^KK101323 has garland cell phenotype, suppressible by PEK^KK100348, Scer\GAL4^sns.PU

(Krausel et al., 2023)

Scer\GAL4^sns.PU, Tcs3^KK101323 has nephrocyte diaphragm phenotype, suppressible by PEK^KK100348, Scer\GAL4^sns.PU

(Krausel et al., 2023)

Scer\GAL4^sns.PU, Tcs3^KK101323 has nephrocyte diaphragm phenotype, suppressible by Hsap\OSGEP^UAS.cKa, Scer\GAL4^sns.PU

(Krausel et al., 2023)

Scer\GAL4^sns.PU, Tcs3^KK101323 has garland cell phenotype, suppressible by Hsap\OSGEP^UAS.cKa, Scer\GAL4^sns.PU

(Krausel et al., 2023)

Scer\GAL4^e22c, Tcs3^KK101323 has wing phenotype, suppressible by BacA\p35^UAS.cHa, Scer\GAL4^e22c

(Rojas-Benítez et al., 2017)

Scer\GAL4^e22c, Tcs3^KK101323 has wing phenotype, suppressible | partially by Hsc70-3^UAS.cEa, Scer\GAL4^e22c

(Rojas-Benítez et al., 2017)

Scer\GAL4^e22c, Tcs3^KK101323 has wing phenotype, suppressible | partially by Xbp1^UAS.HG.EGFP/Scer\GAL4^e22c

(Rojas-Benítez et al., 2017)

NOT suppressed by

Statement

Reference

Scer\GAL4^sns.PU, Tcs3^KK101323 has nephrocyte diaphragm phenotype, non-suppressible by Hsap\OSGEP^R247Q.UAS, Scer\GAL4^sns.PU

(Krausel et al., 2023)

Scer\GAL4^sns.PU, Tcs3^KK101323 has garland cell phenotype, non-suppressible by Hsap\OSGEP^C110R.UAS, Scer\GAL4^sns.PU

(Krausel et al., 2023)

Scer\GAL4^sns.PU, Tcs3^KK101323 has garland cell phenotype, non-suppressible by Hsap\OSGEP^I14F.UAS, Scer\GAL4^sns.PU

(Krausel et al., 2023)

Scer\GAL4^sns.PU, Tcs3^KK101323 has garland cell phenotype, non-suppressible by Hsap\OSGEP^R325Q.UAS, Scer\GAL4^sns.PU

(Krausel et al., 2023)

Scer\GAL4^sns.PU, Tcs3^KK101323 has garland cell phenotype, non-suppressible by Hsap\OSGEP^R247Q.UAS, Scer\GAL4^sns.PU

(Krausel et al., 2023)

Scer\GAL4^sns.PU, Tcs3^KK101323 has nephrocyte diaphragm phenotype, non-suppressible by Hsap\OSGEP^C110R.UAS, Scer\GAL4^sns.PU

(Krausel et al., 2023)

Scer\GAL4^sns.PU, Tcs3^KK101323 has nephrocyte diaphragm phenotype, non-suppressible by Hsap\OSGEP^R325Q.UAS, Scer\GAL4^sns.PU

(Krausel et al., 2023)

Scer\GAL4^sns.PU, Tcs3^KK101323 has nephrocyte diaphragm phenotype, non-suppressible by Hsap\OSGEP^I14F.UAS, Scer\GAL4^sns.PU

(Krausel et al., 2023)

Scer\GAL4^e22c, Tcs3^KK101323 has wing phenotype, non-suppressible by bsk^DN.UAS/Scer\GAL4^e22c

(Rojas-Benítez et al., 2017)

Additional Comments

Genetic Interactions

Statement

Reference

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Rescued by

Tcs3^KK101323 is rescued by Scer\GAL4^e22c/Tcs3^UAS.cRa

(Rojas-Benítez et al., 2017)

Comments

Images (0)

Mutant

Wild-type

Stocks (1)

VDRC

v106250

P{KK101323}VIE-260B

Notes on Origin

Discoverer

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (2)

Reported As

Symbol Synonym

CG4933^KK101323

Tcs3^KK101323

Name Synonyms

Secondary FlyBase IDs

References (3)

Report Sections

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