FlyBase Allele Report: Dmel\shi[KK101444]

General Information

Symbol

Dmel\shi^KK101444

Species

D. melanogaster

Name

FlyBase ID

FBal0231273

Feature type

allele

Associated gene

Dmel\shi

Associated Insertion(s)

Carried in Construct

P{KK101444}

Key Links

Genomic Maps

JBrowse

Transgenic product class

RNAi_reagent

(Keleman et al., 2009.8.5)

Mutagen

in vitro construct

Nature of the Allele

Transgenic product class

RNAi_reagent

(Keleman et al., 2009.8.5)

Mutagen

in vitro construct

(Keleman et al., 2009.8.5)

Progenitor genotype

Carried in construct

P{KK101444}

Cytology

Description

UASt regulatory sequences drive expression of an inverted repeat.

(Keleman et al., 2009.8.5)

Allele components

Component

Use(s)

Regulatory region(s)

UASt

binary expression system - regulatory region

Encoded product / tool

dsRNA-KK101444

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

Phenotype Manifest In

dorsal appendage, with Scer\GAL4^CY2

(Peters et al., 2013)

dorsal appendage, with Scer\GAL4^Vm26Aa.F

(Peters et al., 2013)

epithelium, with Scer\GAL4^NP1624

(Berns et al., 2014)

female germline cyst, with Scer\GAL4^NP1624

(Berns et al., 2014)

Detailed Description

Statement

Reference

Scer\GAL4^tj-NP1624-mediated expression results in the transformation of the normal germline cyst epithelial monolayer into two or more cell layers.

(Berns et al., 2014)

Expression of shi^KK101444 under the control of Scer\GAL4^nSyb.PS results in internalisation of FM1-43 in large membraneous structures in the boutons upon stimulation of the nerve.

(Kasprowicz et al., 2014)

Expression of shi^KK101444 under the control of Scer\GAL4^Vm26Aa.F results in moderate dorsal appendage defects in 27% of cases, with the appendages being broad.

Expression of shi^KK101444 under the control of Scer\GAL4^CY2 results in moderate dorsal appendage defects in 37% of cases, with the appendages being short and rough.

(Peters et al., 2013)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Phenotype Manifest In

Enhanced by

Statement

Reference

Scer\GAL4^Vm26Aa.F, shi^KK101444 has dorsal appendage phenotype, enhanceable by ttk[+]/ttk^twp

(Peters et al., 2013)

Scer\GAL4^CY2, shi^KK101444 has dorsal appendage phenotype, enhanceable by ttk[+]/ttk^twp

(Peters et al., 2013)

Additional Comments

Genetic Interactions

Statement

Reference

The severity of the dorsal appendage defects caused by expression of shi^KK101444 under the control of either Scer\GAL4^Vm26Aa.F or Scer\GAL4^CY2 is enhanced by ttk^twp/+.

(Peters et al., 2013)

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Comments

Images (0)

Mutant

Wild-type

Stocks (1)

VDRC

v105971

P{KK101444}VIE-260B

Notes on Origin

Discoverer

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (2)

Reported As

Symbol Synonym

Shi^RNAi

(Weiss et al., 2019)

shi^KK101444

Name Synonyms

Secondary FlyBase IDs

References (6)

Report Sections

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