FlyBase Allele Report: Dmel\hppy[KK101460]

General Information

Symbol

Dmel\hppy^KK101460

Species

D. melanogaster

Name

FlyBase ID

FBal0231284

Feature type

allele

Associated gene

Dmel\hppy

Associated Insertion(s)

Carried in Construct

P{KK101460}

Key Links

Genomic Maps

JBrowse

Transgenic product class

RNAi_reagent

(Keleman et al., 2009.8.5)

Mutagen

in vitro construct

Nature of the Allele

Transgenic product class

RNAi_reagent

(Keleman et al., 2009.8.5)

Mutagen

in vitro construct

(Keleman et al., 2009.8.5)

Progenitor genotype

Carried in construct

P{KK101460}

Cytology

Description

UASt regulatory sequences drive expression of an inverted repeat.

(Keleman et al., 2009.8.5)

Allele components

Component

Use(s)

Regulatory region(s)

UASt

binary expression system - regulatory region

Encoded product / tool

dsRNA-KK101460

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 1 )

Disease

Interaction

References

exacerbates retinitis pigmentosa

modeled by ninaE^G69D.UAS

(Chow et al., 2016)

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

abnormal starvation stress response | adult stage, with Scer\GAL4^Cg.PU

(Havula et al., 2022)

majority die during P-stage | nutrition conditional, with Scer\GAL4^Tub.PU

(Havula et al., 2022)

partially lethal - majority die | nutrition conditional, with Scer\GAL4^Tub.PU

(Havula et al., 2022)

short lived | calorie restriction conditional, with Scer\GAL4^Cg.PU

(Havula et al., 2022)

Phenotype Manifest In

Detailed Description

Statement

Reference

Expression of hppy^KK101460 under the control of Scer\GAL4^GMR.PF has no effect on the adult eye morphology.

(Chow et al., 2016)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Enhancer of

Statement

Reference

hppy^KK101460/Scer\GAL4^GMR.PF is an enhancer of visible | adult stage phenotype of Scer\GAL4^GMR.PF, ninaE^G69D.UAS

(Chow et al., 2016)

NOT Enhancer of

Statement

Reference

hppy^KK101460/Scer\GAL4^GMR.PF is a non-enhancer of visible | adult stage phenotype of Scer\GAL4^GMR.PF, ninaE^G69D.UAS

(Chow et al., 2016)

hppy^KK101460/Scer\GAL4^GMR.PF is a non-enhancer of abnormal size | adult stage phenotype of Scer\GAL4^GMR.PF, ninaE^G69D.UAS

(Chow et al., 2016)

NOT Suppressor of

Statement

Reference

hppy^KK101460/Scer\GAL4^GMR.PF is a non-suppressor of visible | adult stage phenotype of Scer\GAL4^GMR.PF, ninaE^G69D.UAS

(Chow et al., 2016)

hppy^KK101460/Scer\GAL4^GMR.PF is a non-suppressor of abnormal size | adult stage phenotype of Scer\GAL4^GMR.PF, ninaE^G69D.UAS

(Chow et al., 2016)

Other

Statement

Reference

Scer\GAL4^GMR.PF, hppy^KK101460, ninaE^G69D.UAS has melanotic necrosis | adult stage phenotype

(Chow et al., 2016)

Phenotype Manifest In

NOT Enhancer of

Statement

Reference

hppy^KK101460/Scer\GAL4^GMR.PF is a non-enhancer of eye phenotype of Scer\GAL4^GMR.PF, ninaE^G69D.UAS

(Chow et al., 2016)

NOT Suppressor of

Statement

Reference

hppy^KK101460/Scer\GAL4^GMR.PF is a non-suppressor of eye phenotype of Scer\GAL4^GMR.PF, ninaE^G69D.UAS

(Chow et al., 2016)

Other

Statement

Reference

Scer\GAL4^GMR.PF, hppy^KK101460, ninaE^G69D.UAS has eye phenotype

(Chow et al., 2016)

Additional Comments

Genetic Interactions

Statement

Reference

The small eye size characteristic for adult flies expressing ninaE^{G69D.Scer\UAS} under the control of Scer\GAL4^GMR.PF is not changed by co-expression of hppy^KK101460, however the eye phenotype is qualitatively worsened: black necrotic spots are reproducibly observed in the adult eye.

(Chow et al., 2016)

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Comments

Images (0)

Mutant

Wild-type

Stocks (1)

VDRC

v103580

P{KK101460}VIE-260B

Notes on Origin

Discoverer

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (2)

Reported As

Symbol Synonym

hppy KD

(Chow et al., 2016)

hppy^KK101460

Name Synonyms

Secondary FlyBase IDs

References (3)

Report Sections

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