FB2026_01 , released March 12, 2026
FB2026_01 , released March 12, 2026
Allele: Dmel\PnglKK101641
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General Information
Symbol
Dmel\PnglKK101641
Species
D. melanogaster
Name
FlyBase ID
FBal0231406
Feature type
allele
Associated gene
Dmel\Pngl
Associated Insertion(s)
Carried in Construct
P{KK101641}
Also Known As
UAS-PnglRNAi
Key Links
Genomic Maps

Transgenic product class
RNAi_reagent
(Keleman et al., 2009.8.5)
Mutagen
Nature of the Allele
Transgenic product class
RNAi_reagent
(Keleman et al., 2009.8.5)
Mutagen
in vitro construct
(Keleman et al., 2009.8.5)
Progenitor genotype
Carried in construct
P{KK101641}
Cytology
Description

UASt regulatory sequences drive expression of an inverted repeat.

(Keleman et al., 2009.8.5)
Allele components
Component
Use(s)
Regulatory region(s)
UASt
Encoded product / tool
dsRNA-KK101641
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 1 )
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      The expression of PnglKK101641 under the combined control of Scer\GAL4GMR.PU, Scer\GAL4ey.PU and Dicer-2 (for efficient RNAi) does not lead to any obvious eye morphology defects, as compared to controls.

      (Huang et al., 2018)

      Individuals expressing PnglKK101641 under the control of Scer\GAL4Mef2.PU or Scer\GAL4how-24B (but not when under the control of Scer\GAL4NP3207 or Scer\GAL4NP3270), are lethal and semi-lethal, respectively; their larval midguts also exhibit a decreased acid zone and impaired food clearing during the wandering stage, but only individuals with Scer\GAL4Mef2.PU-driven expression exhibit a shortened gastric caeca, as compared to controls.

      (Galeone et al., 2017)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      NOT Suppressor of
      Additional Comments
      Genetic Interactions
      Statement
      Reference

      The abnormal eye morphology resulting from the expression of ninaEG69D.GMR under the combined control of Scer\GAL4GMR.PU, Scer\GAL4ey.PU is not suppressed by the co-expression of sip3Scer\UAS.T:Hsap\MYC and PnglKK101641 (in combination with Dicer-2, for efficient RNAi).

      (Huang et al., 2018)
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Comments
      Images (0)
      Mutant
      Wild-type
      Stocks (1)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (2)
      Reported As
      Symbol Synonym
      PNGaseKK101641
      PnglKK101641
      Name Synonyms
      Secondary FlyBase IDs
        References (5)