FB2026_01 , released March 12, 2026
FB2026_01 , released March 12, 2026
Allele: Dmel\konKK102101
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General Information
Symbol
Dmel\konKK102101
Species
D. melanogaster
Name
FlyBase ID
FBal0231623
Feature type
allele
Associated gene
Associated Insertion(s)
Carried in Construct
Key Links
Genomic Maps

Transgenic product class
Nature of the Allele
Transgenic product class
Progenitor genotype
Carried in construct
Cytology
Description

UASt regulatory sequences drive expression of an inverted repeat.

Allele components
Component
Use(s)
Encoded product / tool
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
Variant Molecular Consequences
Associated Sequence Data
DNA sequence
Protein sequence
 
Expression Data
Reporter Expression
Additional Information
Statement
Reference
 
Marker for
Reflects expression of
Reporter construct used in assay
Human Disease Associations
Disease Ontology (DO) Annotations
Models Based on Experimental Evidence ( 0 )
Disease
Evidence
References
Modifiers Based on Experimental Evidence ( 0 )
Disease
Interaction
References
Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
 
Disease-implicated variant(s)
 
Phenotypic Data
Phenotypic Class
Phenotype Manifest In
Detailed Description
Statement
Reference

The expression of konKK102101 under the control of Scer\GAL4Mef2.PR leads to defects in indirect flight muscle compaction at 48h APF.

Scer\GAL4tj-NP1624-mediated expression results in holes in the cyst epithelium only detectable after stage 2 - the cyst is not covered by epithelial cells.

Expression of konKK102101 under the control of Scer\GAL4Mef2.PR from the larval stage onwards prevents eclosion from the pupal case. The persistent larval muscles in the abdomen of the pharate adults always show a detached phenotype and are rounded. The dorsal abdominal muscles are often misoriented and in addition are unevenly distributed, resulting in regions of the abdomen devoid of muscles.

Adult expressing konKK102101 under the control of Scer\GAL41151 have misoriented dorsal abdominal muscles which are thinner than normal and unevenly distributed.

Adult myoblasts in pupae expressing konKK102101 under the control of Scer\GAL4Mef2.PR are sometimes misoriented and fail to separate properly.

Expression of konKK102101 under the control of Scer\GAL4Mef2.PR does not affect muscle number or number of nuclei per muscle in the adult abdominal muscles, although the nuclei are not distributed evenly along the muscle length, in contrast to wild type. The muscles are thinner than normal and show defects in sarcomeric organisation: the Z-bands are irregular and discontinuous, the H-zone is severely reduced or missing and the bare zone is absent.

External Data
Interactions
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Phenotypic Class
Phenotype Manifest In
Additional Comments
Genetic Interactions
Statement
Reference
Xenogenetic Interactions
Statement
Reference
Complementation and Rescue Data
Comments
Images (0)
Mutant
Wild-type
Stocks (1)
Notes on Origin
Discoverer
External Crossreferences and Linkouts ( 0 )
Synonyms and Secondary IDs (1)
Reported As
Symbol Synonym
konKK102101
Name Synonyms
Secondary FlyBase IDs
    References (8)