FlyBase Allele Report: Dmel\CG3740[KK103637]

General Information

Symbol

Dmel\CG3740^KK103637

Species

D. melanogaster

Name

FlyBase ID

FBal0232435

Feature type

allele

Associated gene

Dmel\CG3740

Associated Insertion(s)

Carried in Construct

P{KK103637}

Key Links

Genomic Maps

JBrowse

Transgenic product class

RNAi_reagent

(Keleman et al., 2009.8.5)

Mutagen

in vitro construct

Nature of the Allele

Transgenic product class

RNAi_reagent

(Keleman et al., 2009.8.5)

Mutagen

in vitro construct

(Keleman et al., 2009.8.5)

Progenitor genotype

Carried in construct

P{KK103637}

Cytology

Description

UASt regulatory sequences drive expression of an inverted repeat.

(Keleman et al., 2009.8.5)

Allele components

Component

Use(s)

Regulatory region(s)

UASt

binary expression system - regulatory region

Encoded product / tool

dsRNA-KK103637

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 1 )

Disease

Evidence

References

model of neurodegenerative disease

CEA with Nazo^GD4780

(Iuso et al., 2014)

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

Phenotype Manifest In

Detailed Description

Statement

Reference

Expression of CG3740^KK103637 via Scer\GAL4^Act5C.PI does not result in any significant difference in lifespan or climbing activity compared to controls.

(Iuso et al., 2014)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Other

Statement

Reference

CG3740^KK103637, Nazo^GD4780, Scer\GAL4^Act5C.PI has bang sensitive phenotype

(Iuso et al., 2014)

CG3740^KK103637, Nazo^GD4780, Scer\GAL4^Act5C.PI has short lived phenotype

(Iuso et al., 2014)

CG3740^KK103637, Nazo^GD4780, Scer\GAL4^Act5C.PI has abnormal neuroanatomy | progressive phenotype

(Iuso et al., 2014)

CG3740^KK103637, Nazo^GD4780, Scer\GAL4^Act5C.PI has abnormal locomotor behavior | progressive phenotype

(Iuso et al., 2014)

Phenotype Manifest In

Other

Statement

Reference

CG3740^KK103637, Nazo^GD4780, Scer\GAL4^Act5C.PI has adult brain | progressive phenotype

(Iuso et al., 2014)

Additional Comments

Genetic Interactions

Statement

Reference

Co-expression of CG3740^KK103637 and CG11671^GD4780via Scer\GAL4^Act5C.PI results in a significantly reduced median lifespan. 1 month old, but not 1 day old, mutants also perform poorly in a climbing assay.

Co-expression of CG3740^KK103637 and CG11671^GD4780via Scer\GAL4^Act5C.PI results in a high number of vacuoles in 28-day old brains, but does not result in iron deposits.

Flies co-expressing CG3740^KK103637 and CG11671^GD4780via Scer\GAL4^Act5C.PI fail to recover a correct body position promptly after mechanical stress - they frantically move their legs and bodies and jump repeatedly before getting upright and climbing.

(Iuso et al., 2014)

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Comments

Images (0)

Mutant

Wild-type

Stocks (1)

VDRC

v105455

P{KK103637}VIE-260B

Notes on Origin

Discoverer

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (1)

Reported As

Symbol Synonym

CG3740^KK103637

Name Synonyms

Secondary FlyBase IDs

References (2)

Report Sections

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