FlyBase Allele Report: Dmel\Met[KK104562]

General Information

Symbol

Dmel\Met^KK104562

Species

D. melanogaster

Name

FlyBase ID

FBal0233064

Feature type

allele

Associated gene

Dmel\Met

Associated Insertion(s)

Carried in Construct

P{KK104562}

Also Known As

UAS-Met-RNAi

Key Links

Genomic Maps

JBrowse

Transgenic product class

RNAi_reagent

(Keleman et al., 2009.8.5)

Mutagen

in vitro construct

Nature of the Allele

Transgenic product class

RNAi_reagent

(Keleman et al., 2009.8.5)

Mutagen

in vitro construct

(Keleman et al., 2009.8.5)

Progenitor genotype

Carried in construct

P{KK104562}

Cytology

Description

UASt regulatory sequences drive expression of an inverted repeat.

(Keleman et al., 2009.8.5)

Allele components

Component

Use(s)

Regulatory region(s)

UASt

binary expression system - regulatory region

Encoded product / tool

dsRNA-KK104562

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

abnormal immune response | adult stage, with Scer\GAL4^Cg.PA

(Shianiou et al., 2023)

abnormal immune response | adult stage, with Scer\GAL4^esg.PU

(Shianiou et al., 2023)

abnormal neurophysiology | adult stage | conditional, with Scer\GAL4^Or47b.7.467

(Sethi et al., 2019)

decreased fecundity, with Scer\GAL4^esg.PU

(Shianiou et al., 2023)

Phenotype Manifest In

adult olfactory receptor neuron Or47b | adult stage | conditional, with Scer\GAL4^Or47b.7.467

(Sethi et al., 2019)

Detailed Description

Statement

Reference

Females expressing Met^KK104562 under the control of Scer\GAL4^NP0001 or Scer\GAL4^Tk.PS fail to show the expected mating-induced increase in germline stem cells in the germarium, as compared to controls.

(Ameku et al., 2018)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Suppressed by

Statement

Reference

Met^KK104562, Scer\GAL4^Or47b.7.467 has abnormal neurophysiology | adult stage | conditional phenotype, suppressible by fru^TOE.GS02668/Spyo\Cas9^{dCas9::VPR.UAS.Tag:FLAG}, Scer\GAL4^Or47b.7.467

(Sethi et al., 2019)

Phenotype Manifest In

Suppressed by

Statement

Reference

Met^KK104562, Scer\GAL4^Or47b.7.467 has adult olfactory receptor neuron Or47b | adult stage | conditional phenotype, suppressible by fru^TOE.GS02668/Spyo\Cas9^{dCas9::VPR.UAS.Tag:FLAG}, Scer\GAL4^Or47b.7.467

(Sethi et al., 2019)

Additional Comments

Genetic Interactions

Statement

Reference

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Comments

Images (0)

Mutant

Wild-type

Stocks (1)

VDRC

v100638

P{KK104562}VIE-260B

Notes on Origin

Discoverer

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (1)

Reported As

Symbol Synonym

Met^KK104562

Name Synonyms

Secondary FlyBase IDs

References (11)

Report Sections

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