FlyBase Allele Report: Dmel\GLaz[KK106377]

General Information

Symbol

Dmel\GLaz^KK106377

Species

D. melanogaster

Name

FlyBase ID

FBal0234208

Feature type

allele

Associated gene

Dmel\GLaz

Associated Insertion(s)

Carried in Construct

P{KK106377}

Key Links

Genomic Maps

JBrowse

Transgenic product class

RNAi_reagent

(Keleman et al., 2009.8.5)

Mutagen

in vitro construct

Nature of the Allele

Transgenic product class

RNAi_reagent

(Keleman et al., 2009.8.5)

Mutagen

in vitro construct

(Keleman et al., 2009.8.5)

Progenitor genotype

Carried in construct

P{KK106377}

Cytology

Description

UASt regulatory sequences drive expression of an inverted repeat.

(Keleman et al., 2009.8.5)

Allele components

Component

Use(s)

Regulatory region(s)

UASt

binary expression system - regulatory region

Encoded product / tool

dsRNA-KK106377

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

abnormal neuroanatomy | larval stage, with Scer\GAL4^alrm.PD

(Yin et al., 2021)

Phenotype Manifest In

dendrite | larval stage, with Scer\GAL4^alrm.PD

(Yin et al., 2021)

larval brain | larval stage, with Scer\GAL4^alrm.PD

(Yin et al., 2021)

LNv neuron | larval stage, with Scer\GAL4^alrm.PD

(Yin et al., 2021)

Detailed Description

Statement

Reference

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Suppressor of

Statement

Reference

GLaz^KK106377/Scer\GAL4^ey.PU is a suppressor of abnormal neuroanatomy | somatic clone | adult stage phenotype of sicily^E

(Liu et al., 2017)

Phenotype Manifest In

Suppressor of

Statement

Reference

Scer\GAL4^54C/GLaz^KK106377 is a suppressor of adult optic lobe glial cell | cell non-autonomous phenotype of ND-42^ninaE.GD6220

(Liu et al., 2017)

Scer\GAL4^54C/GLaz^KK106377 is a suppressor of lipid droplet | cell non-autonomous | adult stage phenotype of ND-42^ninaE.GD6220

(Liu et al., 2017)

GLaz^KK106377/Scer\GAL4^ey.PU is a suppressor of adult optic lobe glial cell | somatic clone phenotype of sicily^E

(Liu et al., 2017)

NOT Suppressor of

Statement

Reference

GLaz^KK106377/Scer\GAL4^elav.PLu is a non-suppressor of adult optic lobe glial cell | cell non-autonomous phenotype of ND-42^ninaE.GD6220

(Liu et al., 2017)

GLaz^KK106377/Scer\GAL4^elav.PLu is a non-suppressor of lipid droplet | cell non-autonomous | adult stage phenotype of ND-42^ninaE.GD6220

(Liu et al., 2017)

Additional Comments

Genetic Interactions

Statement

Reference

The accumulation of lipid droplets in glial cells in the vicinity of adult photoreceptor neurons expressing ND-42^ninaE.GD6220 is suppressed by Scer\GAL4^54C-driven (glial) but not Scer\GAL4^elav.PLu-driven (neuronal) knock-down of GLaz using GLaz^KK106377.

Expression of GLaz^KK106377 in the ey>flip whole-eye clones mutant for sicily^E ameliorates the lipid droplet accumulation in retinal glial cells in adult flies and also improves the photoreceptor degeneration phenotype.

(Liu et al., 2017)

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Comments

Images (0)

Mutant

Wild-type

Stocks (1)

VDRC

v107433

P{KK106377}VIE-260B

Notes on Origin

Discoverer

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (2)

Reported As

Symbol Synonym

GLaz^KK106377

GLaz^RNAi

(Yin et al., 2021)

Name Synonyms

Secondary FlyBase IDs

References (5)

Report Sections

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