FlyBase Allele Report: Dmel\Ret[KK107206]

General Information

Symbol

Dmel\Ret^KK107206

Species

D. melanogaster

Name

FlyBase ID

FBal0234791

Feature type

allele

Associated gene

Dmel\Ret

Associated Insertion(s)

Carried in Construct

P{KK107206}

Key Links

Genomic Maps

JBrowse

Transgenic product class

RNAi_reagent

(Keleman et al., 2009.8.5)

Mutagen

in vitro construct

Nature of the Allele

Transgenic product class

RNAi_reagent

(Keleman et al., 2009.8.5)

Mutagen

in vitro construct

(Keleman et al., 2009.8.5)

Progenitor genotype

Carried in construct

P{KK107206}

Cytology

Description

UASt regulatory sequences drive expression of an inverted repeat.

(Keleman et al., 2009.8.5)

Allele components

Component

Use(s)

Regulatory region(s)

UASt

binary expression system - regulatory region

Encoded product / tool

dsRNA-KK107206

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 1 )

Disease

Evidence

References

model of Hirschsprung's disease

CEA

(Myers et al., 2018)

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

abnormal cell migration | embryonic stage, with Scer\GAL4^Ret.P2

(Myers et al., 2018)

abnormal neuroanatomy, with Scer\GAL4^21-7

(Soba et al., 2015)

abnormal neuroanatomy | embryonic stage, with Scer\GAL4^Ret.P2

(Myers et al., 2018)

abnormal size | embryonic stage, with Scer\GAL4^Ret.P2

(Myers et al., 2018)

Phenotype Manifest In

Detailed Description

Statement

Reference

Expressing Ret^KK107206 under the control of Scer\GAL4^Ret.P2 leads to missing or shortened frontal nerves as well as disrupted frontal ganglia and esophageal ganglia that do not migrate as far as in the control.

(Myers et al., 2018)

Expression of Ret^KK107206 under the control of Scer\GAL4^21-7 causes class IV dendritic arborizing neuron dendrite patterning defects.

(Soba et al., 2015)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Phenotype Manifest In

Additional Comments

Genetic Interactions

Statement

Reference

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Comments

Images (0)

Mutant

Wild-type

Stocks (1)

VDRC

v107648

P{KK107206}VIE-260B

Notes on Origin

Discoverer

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (1)

Reported As

Symbol Synonym

Ret^KK107206

Name Synonyms

Secondary FlyBase IDs

References (4)

Report Sections

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