FlyBase Allele Report: Dmel\okr[KK107487]

General Information

Symbol

Dmel\okr^KK107487

Species

D. melanogaster

Name

FlyBase ID

FBal0234964

Feature type

allele

Associated gene

Dmel\okr

Associated Insertion(s)

Carried in Construct

P{KK107487}

Also Known As

UAS-okra^RNAi

Key Links

Genomic Maps

JBrowse

Transgenic product class

RNAi_reagent

(Keleman et al., 2009.8.5)

Mutagen

in vitro construct

Nature of the Allele

Transgenic product class

RNAi_reagent

(Keleman et al., 2009.8.5)

Mutagen

in vitro construct

(Keleman et al., 2009.8.5)

Progenitor genotype

Carried in construct

P{KK107487}

Cytology

Description

UASt regulatory sequences drive expression of an inverted repeat.

(Keleman et al., 2009.8.5)

Allele components

Component

Use(s)

Regulatory region(s)

UASt

binary expression system - regulatory region

Encoded product / tool

dsRNA-KK107487

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 1 )

Disease

Evidence

References

model of cancer

CEA with BacA\p35^UAS.cHa

(Dekanty et al., 2015)

Modifiers Based on Experimental Evidence ( 1 )

Disease

Interaction

References

model of cancer

is ameliorated by bsk^K53R.UAS

(Dekanty et al., 2015)

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

Phenotype Manifest In

Detailed Description

Statement

Reference

The expression of okr^KK107487 under the control of Scer\GAL4^ey.PH does not have an obvious effect on the adult eye size compared to controls.

(Clemente-Ruiz et al., 2016)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Suppressed by

Statement

Reference

BacA\p35^UAS.cHa, Scer\GAL4^en.PU, okr^KK107487 has hyperplasia | larval stage | conditional phenotype, suppressible by bsk^K53R.UAS, Scer\GAL4^en.PU

(Dekanty et al., 2015)

Enhancer of

Statement

Reference

okr^KK107487/Scer\GAL4^ey.PH is an enhancer | female of increased cell death | larval stage phenotype of Scer\GAL4^e22c, rod^GD8768

(Clemente-Ruiz et al., 2016)

okr^KK107487, Scer\GAL4^ey.PH is an enhancer | female of abnormal size | adult stage phenotype of Bub3^GD9924, Scer\GAL4^ey.PH

(Clemente-Ruiz et al., 2016)

okr^KK107487, Scer\GAL4^ey.PH is an enhancer | female of visible phenotype of Bub3^GD9924, Scer\GAL4^ey.PH

(Clemente-Ruiz et al., 2016)

okr^KK107487, Scer\GAL4^ap-md544 is an enhancer of abnormal DNA repair | larval stage phenotype of BacA\p35^UAS.cHa, Scer\GAL4^ap-md544, rod^GD8768

(Clemente-Ruiz et al., 2016)

okr^KK107487, Scer\GAL4^en.PU is an enhancer of hyperplasia | larval stage | conditional phenotype of BacA\p35^UAS.cHa, Scer\GAL4^en.PU

(Dekanty et al., 2015)

Other

Statement

Reference

BacA\p35^UAS.cHa, Scer\GAL4^ap-md544, okr^KK107487, rod^GD8768 has abnormal size | larval stage phenotype

(Clemente-Ruiz et al., 2016)

BacA\p35^UAS.cHa, Scer\GAL4^en.PU, okr^KK107487 has abnormal DNA repair | larval stage | conditional phenotype

(Dekanty et al., 2015)

Phenotype Manifest In

Suppressed by

Statement

Reference

BacA\p35^UAS.cHa, Scer\GAL4^en.PU, okr^KK107487 has wing disc posterior compartment | conditional phenotype, suppressible by bsk^K53R.UAS, Scer\GAL4^en.PU

(Dekanty et al., 2015)

Enhancer of

Statement

Reference

okr^KK107487/Scer\GAL4^ey.PH is an enhancer | female of wing disc posterior compartment phenotype of Scer\GAL4^e22c, rod^GD8768

(Clemente-Ruiz et al., 2016)

okr^KK107487, Scer\GAL4^ey.PH is an enhancer | female of eye phenotype of Bub3^GD9924, Scer\GAL4^ey.PH

(Clemente-Ruiz et al., 2016)

okr^KK107487, Scer\GAL4^ap-md544 is an enhancer of wing disc dorsal compartment phenotype of BacA\p35^UAS.cHa, Scer\GAL4^ap-md544, rod^GD8768

(Clemente-Ruiz et al., 2016)

okr^KK107487, Scer\GAL4^en.PU is an enhancer of wing disc posterior compartment | conditional phenotype of BacA\p35^UAS.cHa, Scer\GAL4^en.PU

(Dekanty et al., 2015)

Other

Statement

Reference

BacA\p35^UAS.cHa, Scer\GAL4^ap-md544, okr^KK107487, rod^GD8768 has wing disc posterior compartment phenotype

(Clemente-Ruiz et al., 2016)

BacA\p35^UAS.cHa, Scer\GAL4^en.PU, okr^KK107487 has wing disc posterior compartment | conditional phenotype

(Dekanty et al., 2015)

Additional Comments

Genetic Interactions

Statement

Reference

Xenogenetic Interactions

Statement

Reference

The co-expression of okr^KK107487 enhances the ionizing irradiation-induced enlarged wing disc posterior compartment observed in individuals expressing BacA\p35^UAS.cHa under the control of Scer\GAL4^en.PU; this phenotype is suppressed by the additional co-expression of bsk^K53R.UAS.

The Scer\GAL4^en.PU-driven co-expression of BacA\p35^UAS.cHa and okr^KK107487 leads to a longer sustained DNA damage response to ionizing ration (assessed by phospho-H2Av immunostaining) in the wing disc posterior compartment as compared to the BacA\p35^UAS.cHa single expression or wild-type backgrounds; this phenotype is suppressed by the additional co-expression of bsk^K53R.UAS.

(Dekanty et al., 2015)

Complementation and Rescue Data

Comments

Images (0)

Mutant

Wild-type

Stocks (1)

VDRC

v104323

P{KK107487}VIE-260B

Notes on Origin

Discoverer

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (1)

Reported As

Symbol Synonym

okr^KK107487

Name Synonyms

Secondary FlyBase IDs

References (3)

Report Sections

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