FB2026_01 , released March 12, 2026
FB2026_01 , released March 12, 2026
Allele: Dmel\Pi3K59FKK107602
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General Information
Symbol
Dmel\Pi3K59FKK107602
Species
D. melanogaster
Name
FlyBase ID
FBal0235039
Feature type
allele
Associated gene
Dmel\Pi3K59F
Associated Insertion(s)
Carried in Construct
P{KK107602}
Also Known As
Vps34 RNAi
Key Links
Genomic Maps

Transgenic product class
RNAi_reagent
(Keleman et al., 2009.8.5)
Mutagen
Nature of the Allele
Transgenic product class
RNAi_reagent
(Keleman et al., 2009.8.5)
Mutagen
in vitro construct
(Keleman et al., 2009.8.5)
Progenitor genotype
Carried in construct
P{KK107602}
Cytology
Description

UASt regulatory sequences drive expression of an inverted repeat.

(Keleman et al., 2009.8.5)
Allele components
Component
Use(s)
Regulatory region(s)
UASt
Encoded product / tool
dsRNA-KK107602
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 1 )
      Disease
      Interaction
      References
      exacerbates  Parkinson's disease
      modeled by Hsap\SNCAUAS.cFa
      (M'Angale and Staveley, 2016)
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      Adulthood-only expression of Pi3K59FKK107602 under the combined control of Scer\GAL4tub.PU and Gal80[ts] leads to intestinal barrier disfunction (as shown by the abnormal permeability to a non-absorbable food dye) and leads to the failure to induce autophagy (assessed by the lysosome and autophagosome marker, Lysotracker) in the adult fat body in response to starvation, as compared to controls. Adulthood-only expression of Pi3K59FKK107602 under the combined control of Scer\GAL4Myo31DF-NP0001 and Gal80[ts] leads to a significantly increased in the posterior midgut cell size, as compared to controls.

      (Wen et al., 2017)

      The expression of Pi3K59FKK107602 under the control of Scer\GAL4GMR.PU leads to a significant decrease in the number of ommatidia and disrupts the ommatidial array, as compared to controls. Expression under the control of Scer\GAL4Ddc.PL leads to a significant decrease in longevity and to a progressive decrease in adult locomotor ability in climbing assays, as compared to controls.

      (M'Angale and Staveley, 2016)

      Co-expression of Pi3K59FKK107602 does not rescue the detachment of the dorsal temporary internal oblique muscles which is seen in pharate adults expressing mtmdsRNA.cVa.Scer\UAS under the control of Scer\GAL4Mef2.PR.

      (Ribeiro et al., 2011)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      Additional Comments
      Genetic Interactions
      Statement
      Reference

      Both the decreased longevity and the progressive decrease in adult locomotion induced by the expression of Pi3K59FKK107602 under the control of Scer\GAL4Ddc.PL are suppressed by the co-expression of BuffyScer\UAS.cQa. The decreased number of ommatidia and the disrupted ommatidial array induced by the expression of Pi3K59FKK107602 under the control of Scer\GAL4GMR.PU are also suppressed by the co-expression of BuffyScer\UAS.cQa.

      (M'Angale and Staveley, 2016)
      Xenogenetic Interactions
      Statement
      Reference

      The co-expression of Pi3K59FKK107602 and Hsap\SNCAScer\UAS.cFa under the control of Scer\GAL4GMR.PU leads to a decrease in the number of ommatidia and consequent disruption of the ommatidial array, both of which are more severe than upon each single expression condition.

      The co-expression of Pi3K59FKK107602 enhances the decreased longevity, but not the progressive decrease in adult locomotion, induced by the expression of Hsap\SNCAScer\UAS.cFa under the control of Scer\GAL4Ddc.PL.

      (M'Angale and Staveley, 2016)
      Complementation and Rescue Data
      Comments
      Images (0)
      Mutant
      Wild-type
      Stocks (1)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (2)
      Reported As
      Symbol Synonym
      Pi3K59FKK107602
      Vps34KK107602
      (Szabó et al., 2023)
      Name Synonyms
      Secondary FlyBase IDs
        References (10)