FlyBase Allele Report: Dmel\fz[KK108004]

General Information

Symbol

Dmel\fz^KK108004

Species

D. melanogaster

Name

FlyBase ID

FBal0235303

Feature type

allele

Associated gene

Dmel\fz

Associated Insertion(s)

Carried in Construct

P{KK108004}

Also Known As

Fz RNAi, UAS-fz1-RNAi

Key Links

Genomic Maps

JBrowse

Transgenic product class

RNAi_reagent

(Keleman et al., 2009.8.5)

Mutagen

in vitro construct

Nature of the Allele

Transgenic product class

RNAi_reagent

(Keleman et al., 2009.8.5)

Mutagen

in vitro construct

(Keleman et al., 2009.8.5)

Progenitor genotype

Carried in construct

P{KK108004}

Cytology

Description

UASt regulatory sequences drive expression of an inverted repeat.

(Keleman et al., 2009.8.5)

Allele components

Component

Use(s)

Regulatory region(s)

UASt

binary expression system - regulatory region

Encoded product / tool

dsRNA-KK108004

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 1 )

Disease

Interaction

References

ameliorates high grade glioma

modeled by Pi3K92E^{UAS.Tag:MYC,Tag:PM(hKRAS)}, btl::Egfr^λ.UAS

(Losada-Pérez et al., 2022, Portela et al., 2019)

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

abnormal cell shape | embryonic stage, with Scer\GAL4^svp.PT

(Trujillo et al., 2016)

abnormal neuroanatomy | third instar larval stage, with Scer\GAL4^Toll-6-D42

(Portela et al., 2019)

partially lethal - majority live, with Scer\GAL4^repo

(Portela et al., 2019)

Phenotype Manifest In

embryonic/larval neuromuscular junction | third instar larval stage, with Scer\GAL4^Toll-6-D42

(Portela et al., 2019)

larval ostial pore | embryonic stage, with Scer\GAL4^svp.PT

(Trujillo et al., 2016)

synapse | adult stage, with Scer\GAL4^Toll-6-D42

(Portela et al., 2019)

Detailed Description

Statement

Reference

Expressing fz^KK108004 under the control of Scer\GAL4^Toll-6-D42 leads to third instar larval neuromuscular junctions showing significantly fewer synapses, as compared to controls.

(Portela et al., 2019)

Expression of fz^KK108004 under the Scer\GAL4^svp.PT driver results in a significant change in ostia cell shape (cells are rounder than in controls).

(Trujillo et al., 2016)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Suppressor of

Statement

Reference

fz^KK108004, Scer\GAL4^repo is a suppressor of neoplasia | third instar larval stage phenotype of Pi3K92E^{UAS.Tag:MYC,Tag:PM(hKRAS)}, Scer\GAL4^repo, btl::Egfr^λ.UAS

(Portela et al., 2019)

fz^KK108004, Scer\GAL4^repo is a suppressor | partially of increased mortality during development phenotype of Pi3K92E^{UAS.Tag:MYC,Tag:PM(hKRAS)}, Scer\GAL4^repo, btl::Egfr^λ.UAS

(Portela et al., 2019)

fz^KK108004/arm^{S10.UAS.Tag:MYC}, Scer\GAL4^repo is a suppressor | partially of abnormal neuroanatomy | third instar larval stage phenotype of Pi3K92E^{UAS.Tag:MYC,Tag:PM(hKRAS)}, Scer\GAL4^repo, btl::Egfr^λ.UAS

(Portela et al., 2019)

fz^KK108004, Scer\GAL4^repo is a suppressor | partially of abnormal neuroanatomy | third instar larval stage phenotype of Pi3K92E^{UAS.Tag:MYC,Tag:PM(hKRAS)}, Scer\GAL4^repo, btl::Egfr^λ.UAS

(Portela et al., 2019)

NOT Suppressor of

Statement

Reference

fz^KK108004/arm^{S10.UAS.Tag:MYC}, Scer\GAL4^repo is a non-suppressor of neoplasia | third instar larval stage phenotype of Pi3K92E^{UAS.Tag:MYC,Tag:PM(hKRAS)}, Scer\GAL4^repo, btl::Egfr^λ.UAS

(Portela et al., 2019)

Other

Statement

Reference

Pi3K92E^{UAS.Tag:MYC,Tag:PM(hKRAS)}, Scer\GAL4^repo, btl::Egfr^λ.UAS, fz^KK108004 has partially lethal - majority live phenotype

(Portela et al., 2019)

Phenotype Manifest In

Suppressor of

Statement

Reference

fz^KK108004, Scer\GAL4^repo is a suppressor | partially of larval brain | third instar larval stage phenotype of Pi3K92E^{UAS.Tag:MYC,Tag:PM(hKRAS)}, Scer\GAL4^repo, btl::Egfr^λ.UAS

(Portela et al., 2019)

fz^KK108004, Scer\GAL4^repo is a suppressor | partially of synapse | third instar larval stage phenotype of Pi3K92E^{UAS.Tag:MYC,Tag:PM(hKRAS)}, Scer\GAL4^repo, btl::Egfr^λ.UAS

(Portela et al., 2019)

fz^KK108004, Scer\GAL4^repo is a suppressor | partially of embryonic/larval neuromuscular junction | third instar larval stage phenotype of Pi3K92E^{UAS.Tag:MYC,Tag:PM(hKRAS)}, Scer\GAL4^repo, btl::Egfr^λ.UAS

(Portela et al., 2019)

fz^KK108004/arm^{S10.UAS.Tag:MYC}, Scer\GAL4^repo is a suppressor | partially of synapse | third instar larval stage phenotype of Pi3K92E^{UAS.Tag:MYC,Tag:PM(hKRAS)}, Scer\GAL4^repo, btl::Egfr^λ.UAS

(Portela et al., 2019)

fz^KK108004/arm^{S10.UAS.Tag:MYC}, Scer\GAL4^repo is a suppressor | partially of embryonic/larval neuromuscular junction | third instar larval stage phenotype of Pi3K92E^{UAS.Tag:MYC,Tag:PM(hKRAS)}, Scer\GAL4^repo, btl::Egfr^λ.UAS

(Portela et al., 2019)

fz^KK108004, Scer\GAL4^repo is a suppressor | partially of larval glial cell | third instar larval stage phenotype of Pi3K92E^{UAS.Tag:MYC,Tag:PM(hKRAS)}, Scer\GAL4^repo, btl::Egfr^λ.UAS

(Portela et al., 2019)

fz^KK108004, Scer\GAL4^repo is a suppressor | partially of glial cell projection | third instar larval stage phenotype of Pi3K92E^{UAS.Tag:MYC,Tag:PM(hKRAS)}, Scer\GAL4^repo, btl::Egfr^λ.UAS

(Portela et al., 2019)

NOT Suppressor of

Statement

Reference

fz^KK108004/arm^{S10.UAS.Tag:MYC}, Scer\GAL4^repo is a non-suppressor of larval brain | third instar larval stage phenotype of Pi3K92E^{UAS.Tag:MYC,Tag:PM(hKRAS)}, Scer\GAL4^repo, btl::Egfr^λ.UAS

(Portela et al., 2019)

fz^KK108004/arm^{S10.UAS.Tag:MYC}, Scer\GAL4^repo is a non-suppressor of larval glial cell | third instar larval stage phenotype of Pi3K92E^{UAS.Tag:MYC,Tag:PM(hKRAS)}, Scer\GAL4^repo, btl::Egfr^λ.UAS

(Portela et al., 2019)

fz^KK108004/arm^{S10.UAS.Tag:MYC}, Scer\GAL4^repo is a non-suppressor of glial cell projection | third instar larval stage phenotype of Pi3K92E^{UAS.Tag:MYC,Tag:PM(hKRAS)}, Scer\GAL4^repo, btl::Egfr^λ.UAS

(Portela et al., 2019)

Additional Comments

Genetic Interactions

Statement

Reference

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Comments

Images (0)

Mutant

Wild-type

Stocks (1)

VDRC

v105493

P{KK108004}VIE-260B

Notes on Origin

Discoverer

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (1)

Reported As

Symbol Synonym

fz^KK108004

(González-Morales et al., 2015)

Name Synonyms

Secondary FlyBase IDs

References (9)

Report Sections

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