FlyBase Allele Report: Dmel\clu[KK108024]

General Information

Symbol

Dmel\clu^KK108024

Species

D. melanogaster

Name

FlyBase ID

FBal0235319

Feature type

allele

Associated gene

Dmel\clu

Associated Insertion(s)

Carried in Construct

P{KK108024}

Key Links

Genomic Maps

JBrowse

Transgenic product class

RNAi_reagent

(Keleman et al., 2009.8.5)

Mutagen

in vitro construct

Nature of the Allele

Transgenic product class

RNAi_reagent

(Keleman et al., 2009.8.5)

Mutagen

in vitro construct

(Keleman et al., 2009.8.5)

Progenitor genotype

Carried in construct

P{KK108024}

Cytology

Description

UASt regulatory sequences drive expression of an inverted repeat.

(Keleman et al., 2009.8.5)

Allele components

Component

Use(s)

Regulatory region(s)

UASt

binary expression system - regulatory region

Encoded product / tool

dsRNA-KK108024

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 1 )

Disease

Interaction

References

exacerbates Parkinson's disease

modeled by Pink1^RNAi.UAS.cYa

(Sen et al., 2015)

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

visible, with Scer\GAL4^Mhc.PW

(Sen et al., 2015)

visible, with Scer\GAL4^Tub.PU

(Sen et al., 2015)

Phenotype Manifest In

wing, with Scer\GAL4^Mhc.PW

(Sen et al., 2015)

wing, with Scer\GAL4^Tub.PU

(Sen et al., 2015)

Detailed Description

Statement

Reference

Expression of clu^KK108024 driven by Scer\GAL4^Mhc.PW or Scer\GAL4^tub.PU significantly increases abnormal wing posture compared to controls.

(Sen et al., 2015)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Enhanced by

Statement

Reference

Scer\GAL4^Mhc.PW, clu^KK108024 has visible phenotype, enhanceable by Pink1^RNAi.UAS.cYa, Scer\GAL4^Mhc.PW

(Sen et al., 2015)

Scer\GAL4^Tub.PU, clu^KK108024 has visible phenotype, enhanceable by Scer\GAL4^Tub.PU/park^KK107919

(Sen et al., 2015)

Enhancer of

Statement

Reference

clu^KK108024, Scer\GAL4^Mhc.PW is an enhancer of visible phenotype of Pink1^RNAi.UAS.cYa, Scer\GAL4^Mhc.PW

(Sen et al., 2015)

clu^KK108024/Scer\GAL4^Tub.PU is an enhancer of visible phenotype of Scer\GAL4^Tub.PU, park^KK107919

(Sen et al., 2015)

Phenotype Manifest In

Enhanced by

Statement

Reference

Scer\GAL4^Mhc.PW, clu^KK108024 has wing phenotype, enhanceable by Pink1^RNAi.UAS.cYa, Scer\GAL4^Mhc.PW

(Sen et al., 2015)

Scer\GAL4^Tub.PU, clu^KK108024 has wing phenotype, enhanceable by Scer\GAL4^Tub.PU/park^KK107919

(Sen et al., 2015)

Enhancer of

Statement

Reference

clu^KK108024, Scer\GAL4^Mhc.PW is an enhancer of wing phenotype of Pink1^RNAi.UAS.cYa, Scer\GAL4^Mhc.PW

(Sen et al., 2015)

clu^KK108024/Scer\GAL4^Tub.PU is an enhancer of wing phenotype of Scer\GAL4^Tub.PU, park^KK107919

(Sen et al., 2015)

Additional Comments

Genetic Interactions

Statement

Reference

Co-expression of Pink1^{dsRNA.Scer\UAS} or park^KK107919 increases the percentage of abnormal wing posture seen in flies with clu^KK108024 driven by Scer\GAL4^Mhc.PW or Scer\GAL4^tub.PU, respectively.

(Sen et al., 2015)

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Comments

Images (0)

Mutant

Wild-type

Stocks (1)

VDRC

v100709

P{KK108024}VIE-260B

Notes on Origin

Discoverer

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (2)

Reported As

Symbol Synonym

CG8443^KK108024

clu^KK108024

Name Synonyms

Secondary FlyBase IDs

References (2)

Report Sections

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